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Titolo:
A high incidence of apolipoprotein E epsilon 4 allele in middle-aged non-demented subjects with cerebral amyloid beta protein deposits
Autore:
Arai, T; Ikeda, K; Akiyama, H; Haga, C; Usami, M; Sahara, N; Iritani, S; Mori, H;
Indirizzi:
Tokyo Inst Psychiat, Dept Neuropathol, Setagaya Ku, Tokyo 1568585, Japan Tokyo Inst Psychiat Tokyo Japan 1568585 etagaya Ku, Tokyo 1568585, Japan Tokyo Inst Psychiat, Dept Mol Biol, Setagaya Ku, Tokyo 1568585, Japan Tokyo Inst Psychiat Tokyo Japan 1568585 etagaya Ku, Tokyo 1568585, Japan Tokyo Metropolitan Matsuzawa Hosp, Setagaya Ku, Tokyo 1560057, Japan TokyoMetropolitan Matsuzawa Hosp Tokyo Japan 1560057 kyo 1560057, Japan
Titolo Testata:
ACTA NEUROPATHOLOGICA
fascicolo: 1, volume: 97, anno: 1999,
pagine: 82 - 84
SICI:
0001-6322(199901)97:1<82:AHIOAE>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; A-BETA; PLAQUES; ONSET; PREVALENCE; TANGLES; BRAINS;
Keywords:
apolipoprotein E; Alzheimer's disease; amyloid beta protein; middle-age;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Arai, T Tokyoyonst Psychiat, Dept Neuropathol, Setagaya Ku, 2-1-8 Kamikitazawa, Tok Tokyo Inst Psychiat 2-1-8 Kamikitazawa Tokyo Japan 1568585 a, Tok
Citazione:
T. Arai et al., "A high incidence of apolipoprotein E epsilon 4 allele in middle-aged non-demented subjects with cerebral amyloid beta protein deposits", ACT NEUROP, 97(1), 1999, pp. 82-84

Abstract

We examined the apolipoprotein E (ApoE) genotypes of 19 middle-aged non-demented subjects with cerebral amyloid beta protein (A beta) deposits, and compared the results with those of 16 patients with sporadic Alzheimer's disease (AD) and those of 34 age-matched controls. The frequency of the ApoE epsilon 4 allele was higher (P = 0.0256) in these 19 subjects (0.211) than in controls (0.059), and was close to that in AD patients (0.281). This result suggests that middle-aged non-demented subjects with cerebral A beta deposits are at high risk of developing AD, and that the diffuse A beta deposits in these cases represent an early stage of AD pathology. We speculate that in the majority of late-onset sporadic AD patients, cerebral A beta deposition commences when these patients are in their forties or fifties, and that the pathological process progresses gradually, taking 20 to 30 years for clinical manifestation of dementia.

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Documento generato il 16/07/20 alle ore 06:31:57