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Titolo:
Depressive symptoms and plasma monoamine levels as predictors of response to clozapine treatment in adolescents with schizophrenia
Autore:
Fleischhaker, C; Schulz, E; Remschmidt, H;
Indirizzi:
Univrburg,rg, Klin Psychiat & Psychotherapie Kindes & Jugendalt, D-35033 Ma Univ Marburg Marburg Germany D-35033 apie Kindes & Jugendalt, D-35033 Ma
Titolo Testata:
ZEITSCHRIFT FUR KINDER-UND JUGENDPSYCHIATRIE UND PSYCHOTHERAPIE
fascicolo: 4, volume: 26, anno: 1998,
pagine: 235 - 243
SICI:
1422-4917(199812)26:4<235:DSAPML>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
GER
Soggetto:
CHILDHOOD-ONSET SCHIZOPHRENIA; CLINICAL-RESPONSE; OPEN TRIAL; METABOLITES; NOREPINEPHRINE;
Keywords:
schizophrenia; adolescents; biogenic amines; clozapine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Fleischhaker, C Univ Marburg, Klin Psychiat & Psychotherapie Kindes & Jugendalt, Hans Sachs Univ Marburg Hans Sachs Str 6 Marburg Germany D-35033 chs
Citazione:
C. Fleischhaker et al., "Depressive symptoms and plasma monoamine levels as predictors of response to clozapine treatment in adolescents with schizophrenia", Z KIND JUG, 26(4), 1998, pp. 235-243

Abstract

Objectives: The purpose of this study was to assess the relationships between neuroleptic medication, biogenic amines and symptomatology in a sample of adolescents with schizophrenia (ICD-IO critria). Method: Psychopathological symptoms were rated weekly by means of standardrating scales (BPRS, SANS, SAPS), parallel to weekly blood samplings for measurement of biogenic amines and serum levels of clozapine. These measureswere obtained for the 6 weeks of conventional neuroleptic treatment and the subsequent 6-week open-label clozapine trial. Results: Serum levels of serotonin and plasma norepinephrine were significantly higher during treatment with clozapine than during preteatment with typical neuroleptics. A comparison of the plasma norepinephrine levels in responders (n = 7) and non-responders (n = 8) to those of clozapine revealed that response to clozapine can be predicted on the basis of the epinephrinelevels prior to initiation of clozapine treatment. Additionally, plasma concentrations of methoxyhydroxyphenylglycol (MHPG) and epinephrine were bothincreased in clozapine responders in comparison to the levels measured during pretreatment with typical neuroleptics. Finally, our results demonstrate that depressive symptomatology prior to initiation of clozapine treatmentis also predictive of response to this atypical neuroleptic. schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:13:47