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Titolo:
SHORT-TERM CARCINOGENICITY TESTING OF A POTENT MURINE INTESTINAL MUTAGEN, 2-AMINO-1-METHYL-6-PHENYLIMIDAZO(4,5-B)PYRIDINE (PHIP), IN APC1638N TRANSGENIC MICE
Autore:
SORENSEN IK; KRISTIANSEN E; MORTENSEN A; VANKRANEN H; VANKREIJL C; FODDE R; THORGEIRSSON SS;
Indirizzi:
NATL FOOD AGCY,INST TOXICOL,MORKHOJ BYGADE 19 DK-2860 SOBORG DENMARK NATL INST PUBL HLTH & ENVIRONM PROTECT NL-3720 BA BILTHOVEN NETHERLANDS LEIDEN UNIV,DEPT HUMAN GENET,MGC NL-2300 RA LEIDEN NETHERLANDS NCI,NIH BETHESDA MD 20892
Titolo Testata:
Carcinogenesis
fascicolo: 4, volume: 18, anno: 1997,
pagine: 777 - 781
SICI:
0143-3334(1997)18:4<777:SCTOAP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL ADENOMATOUS POLYPOSIS; GERM-LINE MUTATIONS; APC GENE; COLORECTAL TUMORIGENESIS; SOMATIC MUTATIONS; COOKED FOOD; ALLELE LOSS; COLI GENE; CANCER; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
I.K. Sorensen et al., "SHORT-TERM CARCINOGENICITY TESTING OF A POTENT MURINE INTESTINAL MUTAGEN, 2-AMINO-1-METHYL-6-PHENYLIMIDAZO(4,5-B)PYRIDINE (PHIP), IN APC1638N TRANSGENIC MICE", Carcinogenesis, 18(4), 1997, pp. 777-781

Abstract

Transgenic Apc1638N mice, heterozygous for a targeted frameshift mutation at codon 1638 of the endogenous adenomatous polyposis coli (APC) gene, are predisposed to develop multiple adenomas and adenocarcinomasalong the intestinal tract and to a number of extra-intestinal lesions including, among others, mammary tumors, We have studied these mice in a short-term carcinogenicity test with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), a potent murine small intestinal mutagen and lymphomagen. Upon dietary administration of 0.03% PhIP in a short-term (6 months) study, a significantly increased number of small intestinal tumors as well as an increased number of aberrant crypt foci (ACF) were observed in male Apc(+)/Apc1638N mice compared with untreated transgenic mice, No differences in intestinal and mammary tumor multiplicity were observed between treated and control Apc(+)/Apc1638N females.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 07:03:41