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Titolo:
Liver conditioning after cardiac arrest: the use of normothermic recirculation in an experimental animal model
Autore:
Garcia-Valdecasas, JC; Tabet, J; Valero, R; Taura, P; Rull, R; Garcia, F; Montserrat, E; Gonzalez, FX; Ordi, J; Beltran, J; Lopez-Boado, MA; Deulofeu, R; Angas, J; Cifuentes, A; Visa, J;
Indirizzi:
Hosppainn Barcelona, Dept Surg, Liver Transplant Unit, E-08036 Barcelona, S Hosp Clin Barcelona Barcelona Spain E-08036 t Unit, E-08036 Barcelona, S
Titolo Testata:
TRANSPLANT INTERNATIONAL
fascicolo: 6, volume: 11, anno: 1998,
pagine: 424 - 432
SICI:
0934-0874(199811)11:6<424:LCACAT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-BEATING DONORS; GLUTATHIONE-S-TRANSFERASE; CORE COOLING TECHNIQUE; HYALURONIC-ACID; CARDIOPULMONARY BYPASS; HEPATOCELLULAR DAMAGE; ADENINE-NUCLEOTIDES; SENSITIVE MARKER; GRAFT FUNCTION; COLD ISCHEMIA;
Keywords:
liver conditioning; cardiac arrest, liver donation; normothermic recirculation; liver transplantation, experimental;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Garcia-Valdecasas, JC Hosp036in Barcelona, Dept Surg, Liver Transplant Unit, Villarroel 170, E-08 Hosp Clin Barcelona Villarroel 170 Barcelona SpainE-08036
Citazione:
J.C. Garcia-Valdecasas et al., "Liver conditioning after cardiac arrest: the use of normothermic recirculation in an experimental animal model", TRANSPLAN I, 11(6), 1998, pp. 424-432

Abstract

The aim of this study was to compare the possible role of normothermic recirculation with the role of liver transplants from nonheart-beating donor pigs after 20 min of cardiac arrest. Three groups were studied, of which twowere control groups: group 1, in which the liver was harvested from a heart-beating donor; group 2, in which the liver was harvested after a period of cardiac arrest followed by total body cooling; and group 3, in which the liver was procured as in group 2, but including a period of 30 min of cardiopulmonary bypass and tissue oxygenation at 37 degrees C before total body cooling. Survival at 5 days; endothelial (hyaluronic acid) and hepatocellular damage (AST, ALT, and cr-GST); adenine nucleotides (energy charge), and histological changes were evaluated. Normothermic recirculation during 30 min showed a significant effect on survival (p =.03), endothelial damage (p <.05), and histological changes after reperfusion (p =.04). Cardiopulmonarybypass significantly increased the energy charge during the normothermic recirculation period (p =.001). Moreover, this study shows that a significant survival (100 %) can be achieved with a liver allograft after 20 min of cardiac arrest. Although the liver suffers a major insult in terms of endothelial damage and hepatocellular damage, lesions caused by the ischemic injury are reversible. Histological changes also indicate lesion reversibility,since they almost disappear after 5 days.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:46:47