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Titolo:
Tityus discrepans venom produces a respiratory distress syndrome in rabbits through an indirect mechanism
Autore:
DSuze, G; Comellas, A; Pesce, L; Sevcik, C; Sanchez-de-Leon, R;
Indirizzi:
Inst Venezolano Invest Cient, Ctr Biofis & Bioquim, Cellular Neuropharmacol Inst Venezolano Invest Cient Caracas Venezuela 1020A ular Neuropharmacol Centelaiv Venezuela, Inst Expt Med, Resp Physiol Unit, Caracas 1050, Venezu Cent Univ Venezuela Caracas Venezuela 1050 ol Unit, Caracas 1050, Venezu
Titolo Testata:
TOXICON
fascicolo: 1, volume: 37, anno: 1999,
pagine: 173 - 180
SICI:
0041-0101(199901)37:1<173:TDVPAR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED PULMONARY-EDEMA; SCORPION ENVENOMATION; CARDIAC DYSFUNCTION; SERRULATUS; BLOOD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: D'Suze, G Inst Venezolano Invest Cient, Ctr Biofis & Bioquim, Cellular Neuropharmacol Inst Venezolano Invest Cient Apartado 21827 Caracas Venezuela 1020A
Citazione:
G. D'Suze et al., "Tityus discrepans venom produces a respiratory distress syndrome in rabbits through an indirect mechanism", TOXICON, 37(1), 1999, pp. 173-180

Abstract

It is well known that scorpion Venom induces lung lesions and respiratory distress which are usually classified as pulmonary oedema (PO). Tityus discrepans is a scorpion that lives in the north-central area of Venezuela, is the most common source of human envenomation here and produces PO. We studied the action of the venom of Tityus discrepans on whole rabbits and on their isolated lungs perfused with Krebs saline with 1 g/l of bovine serum albumin (Krebs-BSA saline). Two milligram of venom were diluted in 250 mi of solution (approximate to the rabbit's total blood volume) and used to perfuse isolated lungs. Lung oedema occurred in rabbits which received 1 mg/kg ofscorpion venom i.p., heparin prevented the production of this lung oedema. T. discrepans venom produced PO, in rabbits pretreated with 15 mg/kg of ajoene. Yet, Tityus venom had no effects on isolated lungs perfused with citrated or heparinized blood, and in lungs perfused with Krebs-BSA with normalCa2+ These result show that Tityus venom does not act directly on lungs. Otherwise, we have observed that abundant microthrombi occurred in all rabbit lungs exposed to venom in vivo, suggesting that these doting alterations are fundamental to produce PO. The presence of intravascular microthrombi is not characteristic of the usual PO hinting that scorpion venom induced pulmonary alterations are a different clinical entity. We thus propose that the use of the term pulmonary oedema in scorpionism should abandoned in favor of scorpion venom respiratory distress syndrome. (C) 1998 Elsevier-Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 08:13:10