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Titolo:
Biochemical determinants of apoptosis and necrosis
Autore:
McConkey, DJ;
Indirizzi:
Univ Texas, Md Anderson Canc Ctr, Dept Cell Biol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 tr, Dept Cell Biol, Houston, TX 77030 USA Univ Texas, Houston Grad Sch Biomed Sci, Toxicol Program, Houston, TX 77030 Univ Texas Houston TX USA 77030 d Sci, Toxicol Program, Houston, TX 77030
Titolo Testata:
TOXICOLOGY LETTERS
fascicolo: 3, volume: 99, anno: 1998,
pagine: 157 - 168
SICI:
0378-4274(19981112)99:3<157:BDOAAN>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; MITOCHONDRIAL PERMEABILITY TRANSITION; ENDOGENOUS ENDONUCLEASE ACTIVATION; CYTOCHROME-C; OXIDATIVE STRESS; CAENORHABDITIS-ELEGANS; THYMOCYTE APOPTOSIS; INTRACELLULAR CALCIUM; GLUTATHIONE DEPLETION; MEDIATED APOPTOSIS;
Keywords:
caspase; bcl-2; ATP; calcium; oxidative stress;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
100
Recensione:
Indirizzi per estratti:
Indirizzo: McConkey, DJ Univd,exas, Md Anderson Canc Ctr, Dept Cell Biol, Box 173,1515 Holcombe Blv Univ Texas Box 173,1515 Holcombe Blvd Houston TX USA 77030 lv
Citazione:
D.J. McConkey, "Biochemical determinants of apoptosis and necrosis", TOX LETT, 99(3), 1998, pp. 157-168

Abstract

Although apoptosis and necrosis were originally thought to be entirely distinct mechanisms of cell death, recent work has shown that the processes are regulated by many of the same biochemical intermediates, most notably thelevels of cellular ATP, Ca2+, reactive oxygen species, and thiol ntioxidants. Beyond a certain threshold, it appears that stress-induced changes in these modulators 'switches' the cell death mechanism from apoptosis to necrosis. Importantly, even when this occurs, cell death can be attenuated by bcl-2 and caspase inhibitors, which are known for their abilities to block apoptosis. This review will summarize these observations within the context of what is currently known about the effector machinery for apoptotic cell death, and possible mechanistic explanations for the switch between apoptosis and necrosis will be provided. (C) 1998 Elsevier Science Ireland Ltd. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:02:48