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Titolo:
Interaction of leukocytes with platelet microparticles derived from outdated platelet concentrates
Autore:
Miyamoto, S; Kowalska, MA; Marcinkiewicz, C; Marcinkiewicz, MM; Mosser, D; Edmunds, LH; Niewiarowski, S;
Indirizzi:
Temple Univ, Sch Med, Sol Sherry Thrombosis Res Ctr, Philadelphia, PA 19140 Temple Univ Philadelphia PA USA 19140 sis Res Ctr, Philadelphia, PA 19140 Temple Univ, Sch Med, Dept Physiol, Philadelphia, PA 19140 USA Temple Univ Philadelphia PA USA 19140 Physiol, Philadelphia, PA 19140 USA Temple Univ, Sch Med, Dept Microbiol & Immunol, Philadelphia, PA 19140 USATemple Univ Philadelphia PA USA 19140 Immunol, Philadelphia, PA 19140 USA Univ04enn, Sch Med, Dept Surg, Harrison Surg Res Labs, Philadelphia, PA 191 Univ Penn Philadelphia PA USA 19104 n Surg Res Labs, Philadelphia, PA 191
Titolo Testata:
THROMBOSIS AND HAEMOSTASIS
fascicolo: 6, volume: 80, anno: 1998,
pagine: 982 - 988
SICI:
0340-6245(199812)80:6<982:IOLWPM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHEMOATTRACTANT PROTEIN-1 MCP-1; BLOOD MONONUCLEAR LEUKOCYTES; ACTIVATED PLATELETS; P-SELECTIN; CARDIOPULMONARY BYPASS; CHEMOTACTIC CYTOKINES; NEUTROPHIL ACTIVATION; PROCOAGULANT ACTIVITY; STIMULATED PLATELETS; ADHESION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Niewiarowski, S Templedelphia,ch Med, Sol Sherry Thrombosis Res Ctr, 3400 N Broad St, Phila Temple Univ 3400 N Broad St Philadelphia PA USA 19140 hila
Citazione:
S. Miyamoto et al., "Interaction of leukocytes with platelet microparticles derived from outdated platelet concentrates", THROMB HAEM, 80(6), 1998, pp. 982-988

Abstract

Platelet microparticles (PMP) were isolated from outdated platelets by a combination of differential centrifugation and gel filtration, and the concentration of PMP was expressed in the equivalent of GPIIb/IIIa complex measured by captured ELISA. PMP bound to isolated neutrophils and macrophages ina dose-dependent manner, but they did not bind to lymphocytes, Incubation of PMP with neutrophils did not activate these cells as measured by up-regulation of Mac-1, release of human granulocyte elastase, and calcium mobilization. Incubation of PMP with macrophages did not enhance IL-8 production and the oxygen burst but slightly and significantly increased production of MCP-I. After 10 min incubation of PMP with macrophages, an increase of GPIIb/IIIa antigen was observed suggesting that PMP may be endocytosed by macrophages. In conclusion, PIMP bind to leukocytes, but, in contrast to activated platelets, do not play a significant role in leukocyte activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:29:11