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Titolo:
Mitochondrial pathology in human schizophrenic striatum: A postmortem ultrastructural study
Autore:
King, L; Roberts, RC;
Indirizzi:
Univle,ryland, Sch Med, Maryland Psychiat Res Ctr, Dept Psychiat, Catonsvil Univ Maryland Catonsville MD USA 21228 Res Ctr, Dept Psychiat, Catonsvil
Titolo Testata:
SYNAPSE
fascicolo: 1, volume: 31, anno: 1999,
pagine: 67 - 75
SICI:
0887-4476(199901)31:1<67:MPIHSS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CYTOCHROME-OXIDASE ACTIVITY; DEVELOPING RAT CEREBELLUM; ELECTRON-TRANSPORT CHAIN; CAUDATE-NUCLEUS; BASAL GANGLIA; COMPLEX-I; ATP SYNTHESIS; HUNTINGTONS-DISEASE; BRAIN MITOCHONDRIA;
Keywords:
metabolism; electron microscopy; basal ganglia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Roberts, RC Univ,Maryland, Sch Med, Maryland Psychiat Res Ctr, Dept Psychiat, POB 21247 Univ Maryland POB 21247 Catonsville MD USA 21228 at, POB 21247
Citazione:
L. King e R.C. Roberts, "Mitochondrial pathology in human schizophrenic striatum: A postmortem ultrastructural study", SYNAPSE, 31(1), 1999, pp. 67-75

Abstract

Studies using in vivo imaging or microscopic analysis of autopsy specimensindicate abnormalities in the striatum of schizophrenics including lower striatal metabolism, a change which can be normalized by antipsychotic medication. To investigate the possibility that abnormalities in schizophrenia brain may be due, in part, to pathology in mitochondria, organelles which generate energy, postmortem brain tissue from schizophrenic and control caseswas obtained from the Maryland Brain Collection. Mitochondria in electron micrographs of striatal neuropil were counted and digitized. The caudate and the putamen of the schizophrenic subjects contained significantly (P < 0.05) fewer (a decrease of approximately 20%) mitochondrial profiles throughout the neuropil than did normal controls. The numbers of mitochondrial profiles per axon terminal appeared lower in the subset of schizophrenics off-drug as compared to either the subset of schizophrenics on-drug or to controls, suggesting that neuroleptic treatment may normalize this measure. The structural integrity of mitochondrial profiles in the schizophrenic striata was not obviously different from that of controls. Fewer mitochondrial profiles suggest decreased energy demands or diminished capacity to respond to energy requirements in the structures that contain them. These data are consistent with other studies showing decreased metabolism in the striatum of schizophrenics and may identify, in part, the anatomical basis of this deficit. Synapse 31:67-75, 1999. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:33:24