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Titolo:
Tracers for imaging melanin with positron emission tomography
Autore:
Sadzot, B; Sheldon, J; Flesher, J; Dannals, RF; Schachat, AP; Frost, JJ;
Indirizzi:
Johns Hopkins Med Inst, Dept Radiol, Div Nucl Med, Baltimore, MD 21287 USAJohns Hopkins Med Inst Baltimore MD USA 21287 ed, Baltimore, MD 21287 USA Johns Hopkins Med Inst, Dept Neurosci, Baltimore, MD 21287 USA Johns Hopkins Med Inst Baltimore MD USA 21287 ci, Baltimore, MD 21287 USA Johns Hopkins Med Inst, Dept Environm Hlth Sci, Baltimore, MD 21287 USA Johns Hopkins Med Inst Baltimore MD USA 21287 ci, Baltimore, MD 21287 USA Johns Hopkins Med Inst, Dept Ophthalmol, Baltimore, MD 21287 USA Johns Hopkins Med Inst Baltimore MD USA 21287 ol, Baltimore, MD 21287 USA
Titolo Testata:
SYNAPSE
fascicolo: 1, volume: 31, anno: 1999,
pagine: 5 - 12
SICI:
0887-4476(199901)31:1<5:TFIMWP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MPTP-INDUCED NEUROTOXICITY; DOPAMINE-RECEPTORS; CHRONIC PARKINSONISM; SEROTONIN RECEPTORS; TOXIC METABOLITE; DRUG-BINDING; NEUROMELANIN; BRAIN; MODEL; PET;
Keywords:
melanin; neuromelanin; melanoma; N-methylspiperone; Parkinson's disease; in vivo labeling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Frost, JJ Johns Hopkins Univ, Sch Med, Dept Radiol, B1-130,600 N Wolfe St,Baltimore, Johns Hopkins Univ B1-130,600 N Wolfe St Baltimore MD USA 21287
Citazione:
B. Sadzot et al., "Tracers for imaging melanin with positron emission tomography", SYNAPSE, 31(1), 1999, pp. 5-12

Abstract

The melanin binding properties of six radioligands were determined in vivoin the eyes of pigmented mice. Binding in the eyes of nonpigmented mice was used to assess nonmelanin binding characteristics. Of these radioligands,H-3-N-methylspiperone showed the best uptake and gave the best signal-to-noise ratio at all time points examined. Its binding appeared essentially irreversible. A PET study with C-11-N-methylspiperone was therefore carried out in a patient with a small ocular melanoma. Increased uptake of C-11-N-methylspiperone was observed in the melanoma. Our studies indicate that PET and radiolabeled NMSP might be used for imaging melanin and for the detection of pigmented melanoma. These results suggest that with a high resolution PET camera it may be feasible to image the melanin-containing cells (dopaminergic neurons) of the substantia nigra in the central nervous system, which could be of interest for the study of Parkinson's disease. Synapse 31:5-12, 1999. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:56:29