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Titolo:
Carcinoids of unknown origin: Comparative analysis with foregut, midgut, and hindgut carcinoids
Autore:
Kirshbom, PM; Kherani, AR; Onaitis, MW; Feldman, JM; Tyler, DS;
Indirizzi:
Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 v, Med Ctr, Dept Surg, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Endocrinol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Ctr, Dept Endocrinol, Durham, NC 27710 USA
Titolo Testata:
SURGERY
fascicolo: 6, volume: 124, anno: 1998,
pagine: 1063 - 1070
SICI:
0039-6060(199812)124:6<1063:COUOCA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY SITE; TUMORS; MANAGEMENT; SEROTONIN; MELANOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Tyler, DS Duke Univ, Med Ctr, Dept Surg, POB 3118, Durham, NC 27710 USA Duke Univ POB 3118 Durham NC USA 27710 118, Durham, NC 27710 USA
Citazione:
P.M. Kirshbom et al., "Carcinoids of unknown origin: Comparative analysis with foregut, midgut, and hindgut carcinoids", SURGERY, 124(6), 1998, pp. 1063-1070

Abstract

Background. Carcinoids are rare neuroendocrine tumors typically arising inthe gastrointestinal tract. A significant percentage of these tumors present as metastatic disease of unknown primary site. The aim of this study wasto better define the functional and clinical characteristics of carcinoidsof unknown primary (CUP) site. Methods, This study examines the hormonal activity clinical characteristics, and survival of 434 patients with carcinoids originating in the foregut,midgut, hindgut, or unknown location. The 143 patients with CUP were compared with the other groups with regard to presenting characteristics, diagnostic tests and therapeutic modalities used, hormonal activity, and survival. Results. The hormone levels (urinary 5-hydroxyindoleacetic acid and serotonin, serum and platelet serotonin) of CUP were not significantly different from midgut carcinoids with metastatic disease. Although survival with CUP was shorter than with carcinoids with identified primaries (10-year survivals of 22 % vs 62 %, 50 %, and 48 % for foregut, midgut, and hindgut, respectively), the survival curve for CUP was quite similar to that of patients with midgut carcinoids with distant disease (10-year survival of 22% vs 28%). Conclusions. CUP are similar to midgut carcinoids presenting with metastatic disease with regard to hormone production and survival. Like other carcinoids, CUP can be an indolent disease process with gradual progression overdecades.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 10:26:33