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Titolo:
Control of lymphocyte function through CD27-CD70 interactions
Autore:
Lens, SMA; Tesselaar, K; van Oers, MHJ; van Lier, RAW;
Indirizzi:
Univ,CLB,erdam, Clin & Expt Immunol Lab, Sanquin Blood Fdn, Dept Immunobiol Univ Amsterdam Amsterdam Netherlands NL-1066 CX ood Fdn, Dept Immunobiol Univrlandsrdam, Acad Med Ctr, Clin Immunol Lab, NL-1105 AZ Amsterdam, Nethe Univ Amsterdam Amsterdam Netherlands NL-1105 AZ 1105 AZ Amsterdam, Nethe Univdsmsterdam, Acad Med Ctr, Dept Hematol, NL-1105 AZ Amsterdam, Netherlan Univ Amsterdam Amsterdam Netherlands NL-1105 AZ AZ Amsterdam, Netherlan
Titolo Testata:
SEMINARS IN IMMUNOLOGY
fascicolo: 6, volume: 10, anno: 1998,
pagine: 491 - 499
SICI:
1044-5323(199812)10:6<491:COLFTC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL ACTIVATION; TUMOR-NECROSIS-FACTOR; FACTOR-RECEPTOR FAMILY; CD70 CD27 LIGAND; SPLENIC B-CELLS; NF-KAPPA-B; ANTIGEN CD27; CYTOKINE PRODUCTION; DEATH DOMAIN; SOLUBLE FORM;
Keywords:
CD27; CD70; lymphocytes; TNFR-family;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
89
Recensione:
Indirizzi per estratti:
Indirizzo: Lens, SMA Univ,CLB,erdam, Clin & Expt Immunol Lab, Sanquin Blood Fdn, DeptImmunobiol Univ Amsterdam Plesmanlaan 125 Amsterdam Netherlands NL-1066 CX
Citazione:
S.M.A. Lens et al., "Control of lymphocyte function through CD27-CD70 interactions", SEMIN IMMUN, 10(6), 1998, pp. 491-499

Abstract

In contrast to the expression of other TNFR/TNF family members, expressionof CD27 and its ligand CD70 is predominantly confined to lymphocytes. Highexpression levels of CD27 appear to be dependent on proper ligation of antigen receptors, whereas for the induction of CD70 expression additional (co-stimulatory and/or pro-inflammatory.) signals are required. Next to membrane-bound CD27 also a soluble form of CD27 is produced in the course of the immune response. Soluble CD27 (sCD27) is found in body fluids and can be used to monitor local and systemic immune activation. lit addition, elevated serum concentrations of sCD27 are found in patients with B cell malignancies and levels of sCD27 strongly correlate with tumor load. Based on functional experiments and in vitro expression regulation data, we propose that interactions between. activated lymphocytes in vivo can result in CD27-CD70 interactions that may regulate the size and function of antigen-primed lymphocyte populations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:21:08