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Titolo:
OX-40: life beyond the effector T cell stage
Autore:
Weinberg, AD; Vella, AT; Croft, M;
Indirizzi:
ProvidencesPortland Med Ctr, Robert W Franz Canc Res Ctr, Earle A Chiles Re Providence Portland Med Ctr Portland OR USA 97213 Ctr, Earle A Chiles Re Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA Oregon State Univ Corvallis OR USA 97331 crobiol, Corvallis, OR 97331 USA La Jolla Inst Allergy & Immunol, San Diego, CA 92121 USA La Jolla Inst Allergy & Immunol San Diego CA USA 92121 iego, CA 92121 USA
Titolo Testata:
SEMINARS IN IMMUNOLOGY
fascicolo: 6, volume: 10, anno: 1998,
pagine: 471 - 480
SICI:
1044-5323(199812)10:6<471:OLBTET>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTOIMMUNE ENCEPHALOMYELITIS; OX40 LIGAND; ACTIVATION MARKER; SPINAL-CORD; ANTIGEN; LYMPHOCYTES; EXPRESSION; MOLECULE; DIFFERENTIATION; IDENTIFICATION;
Keywords:
OX-40; CD4(+) T cells; lymphokines; effector function; disease;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Weinberg, AD ProvidencesPortland Med Ctr, Robert W Franz Canc Res Ctr, Earle A Chiles Re Providence Portland Med Ctr 4805 NE Glisan Portland OR USA 97213
Citazione:
A.D. Weinberg et al., "OX-40: life beyond the effector T cell stage", SEMIN IMMUN, 10(6), 1998, pp. 471-480

Abstract

The OX-40 receptor (OX-40R) is a transmembrane protein found on the surface of activated CD4(+) T cells. When engaged by an agonist such as anti-OX-40 antibody or the OX-40 ligand (OX-40L) during antigen presentation to T cell lines, the OX-40R generates a costimulatory signal that is as potent as CD28 costimulation. Engagement of OX-40R enhances effector and memory-effector T cell function by up-regulating IL-2 production and increasing the life-span of effector T cells. We hypothesize that the signal generated by theOX-40R inhibits activation-induced T cell death (AICD) and thereby increases the number of cells differentiating from the effector to memory T cell stage. In experimental autoimmune encephalomyelitis (EAE) OX-40R(+) T cells are found only within the inflammatory site [central nervous system (CNS)]. Sorting OX-40R+ T cells from the CNS of animals with EAE revealed that they are autoantigen-specific T cells. Therefore, OX-40R-specific therapies were devised to eliminate or inhibit autoreactive T cells, while sparing the remainder of the T cell repertoire. In contrast, in vivo costimulation through the OX-40R in animals with cancer generated enhanced tumor-specific immunity leading to improved tumor-free survival. Thus, manipulation of the OX-40R during inflammatory responses can alter effector CD4(+) T cell function by enhancing or limiting T cell activation and survival.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:23:37