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Titolo:
Tumor necrosis factor receptor family members in the immune system
Autore:
Gravestein, LA; Borst, J;
Indirizzi:
Netherlandsndsnc Inst, Div Cellular Biochem, NL-1066 CX Amsterdam, Netherla Netherlands Canc Inst Amsterdam Netherlands NL-1066 CX sterdam, Netherla
Titolo Testata:
SEMINARS IN IMMUNOLOGY
fascicolo: 6, volume: 10, anno: 1998,
pagine: 423 - 434
SICI:
1044-5323(199812)10:6<423:TNFRFM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; INDUCED CELL-DEATH; DOMAIN-CONTAINING RECEPTOR; GROWTH-FACTOR RECEPTOR; APOPTOSIS-MEDIATING RECEPTOR; LYMPHOCYTE-SPECIFIC MEMBER; GERMINAL CENTER FORMATION; TRAF-INTERACTING PROTEIN; LIGAND-DEFICIENT MICE; HUMAN T-LYMPHOCYTES;
Keywords:
signal transduction; death domain; TRAF; tissue distribution; knock out mice;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
147
Recensione:
Indirizzi per estratti:
Indirizzo: Borst, J Netherlandssterdam,st, Div Cellular Biochem, Plesmanlaan 121, NL-1066 CX Am Netherlands Canc Inst Plesmanlaan 121 Amsterdam Netherlands NL-1066 CX
Citazione:
L.A. Gravestein e J. Borst, "Tumor necrosis factor receptor family members in the immune system", SEMIN IMMUN, 10(6), 1998, pp. 423-434

Abstract

The tumor nemesis factor (TNF) receptor family contains death receptors, which have a cytoplasmic death domain and can induce apoptosis, as well as receptors with no apparent homology in the cytoplasmic tail. This second group of receptors binds TNF receptor-associated factors (TRAFs), which are implicated in gene regulation and anti-apoptotic signaling. A bewildering variety of TNF receptor family members and their ligands are expressed on cells of the immune system. Based on the pattern of expression of receptors andligands and based on the phenotype elf available knock out mice, we summarize at which stages in lymphoid development and/or the peripheral immune response the various TNF receptor family members may play a role.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 08:42:34