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Titolo:
Molecular basis of T cell inactivation by CTLA-4
Autore:
Lee, KM; Chuang, E; Griffin, M; Khattri, R; Hong, DK; Zhang, WG; Straus, D; Samelson, LE; Thompson, CB; Bluestone, JA;
Indirizzi:
Univ637icago, Ben May Inst Canc Res, Howard Hughes Med Inst, Chicago, IL 60 Univ Chicago Chicago IL USA 60637 Howard Hughes Med Inst, Chicago, IL 60 Univ Chicago, Comm Immunol, Chicago, IL 60637 USA Univ Chicago Chicago ILUSA 60637 go, Comm Immunol, Chicago, IL 60637 USA Univ Chicago, Gwen Knapp Ctr Lupus & Immunol Res, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 us & Immunol Res, Chicago, IL 60637 USA NICHHD, Cell Biol & Metab Branch, NIH, Bethesda, MD 20892 USA NICHHD Bethesda MD USA 20892 & Metab Branch, NIH, Bethesda, MD 20892 USA Univ Chicago, Dept Pathol & Med, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 ept Pathol & Med, Chicago, IL 60637 USA
Titolo Testata:
SCIENCE
fascicolo: 5397, volume: 282, anno: 1998,
pagine: 2263 - 2266
SICI:
0036-8075(199812)282:5397<2263:MBOTCI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SH2-CONTAINING PHOSPHOTYROSINE PHOSPHATASE; TYROSINE PHOSPHORYLATION; RECEPTOR; ACTIVATION; KINASES; ZETA; EXPRESSION; SUBUNIT; COMPLEX; DOMAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Bluestone, JA Univ637icago, Ben May Inst Canc Res, Howard Hughes Med Inst,Chicago, IL 60 Univ Chicago Chicago IL USA 60637 Med Inst, Chicago, IL 60
Citazione:
K.M. Lee et al., "Molecular basis of T cell inactivation by CTLA-4", SCIENCE, 282(5397), 1998, pp. 2263-2266

Abstract

CTLA-4, a negative regulator of T cell function, was found to associate with the T cell receptor (TCR) complex zeta chain in primary T cells, The association of TCR zeta with CTLA-4, reconstituted in 293 transfectants, was enhanced by p56(lck)- induced tyrosine phosphorylation. Coexpression of the CTLA-4-associated tyrosine phosphatase, SHP-2, resulted in dephosphorylation of TCR zeta bound to CTLA-4 and abolished the p56(lck)-inducible TCR zeta-CTLA-4 interaction. Thus, CTLA-4 inhibits TCR signal transduction by binding to TCR zeta and inhibiting tyrosine phosphorylation after T cell activation. These findings have broad implications for the negative regulation of T cell function and T cell tolerance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 19:58:47