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Titolo:
Long-term study in subclinical hypothyroidism: spontaneous course and predictors of overt hypothyroidism
Autore:
Huber, G; Mitrache, C; Meier, C; Guglielmetti, M; Huber, P; Staub, JJ;
Indirizzi:
Kantonsspitalnivsel, Univ Kliniken, Dept Innere Med, Abt Endokrinol & Med U Kantonsspital Basel Basel Switzerland nnere Med, Abt Endokrinol & Med U
Titolo Testata:
SCHWEIZERISCHE MEDIZINISCHE WOCHENSCHRIFT
fascicolo: 48, volume: 128, anno: 1998,
pagine: 1902 - 1905
SICI:
0036-7672(19981128)128:48<1902:LSISHS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
GER
Soggetto:
DOUBLE-BLIND; WOMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Huber, G UnivtzerlandMed Klin B, Dept Innere Med, Petersgraben 4, CH-4031 Basel, Swi Univ Basel Petersgraben 4 Basel Switzerland CH-4031 1 Basel, Swi
Citazione:
G. Huber et al., "Long-term study in subclinical hypothyroidism: spontaneous course and predictors of overt hypothyroidism", SCHW MED WO, 128(48), 1998, pp. 1902-1905

Abstract

The syndrome of subclinical hypothyroidism is frequent and predominantly affects females over 40. Only limited data on its natural course is available. It was the aim of our prospective trial to analyze the spontaneous evolution of this syndrome, to identify risk factors of the development of overthypothyroidism and to develop guidelines for the management of such patients. 154 female patients were followed over a mean observation period of 10 years. After 10 years, 34% had developed overt hypothyroidism, 57% remainedin the subclinical stage, and in 9% thyroid function had normalized. The initial grading of TSH-concentration (<6 mU/l, 6-12 mU/l, >12 mU/l)was highly predictive for thyroid failure: 7.3%, 25% and 78%, respectively, overt hypothyroidism occurred. Further risk factors for thyroid failure included animpaired thyroid reserve (T-3-stimulation after TRH) and elevated titers of microsomal antibodies. We therefore recommend to controlling patients with a TSH-concentration <6 mU/l, start thyroxine hormone replacement therapy in patients with a TSH-concentration >12 mU/l and, depending on the additional risk factors, either controlling or treating patients with a TSH-concentration of 6-12 mU/l.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 05:34:31