Catalogo Articoli (Spogli Riviste)

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Titolo:
2,3-Benzodiazepine AMPA antagonists
Autore:
Tarnawa, I; Vizi, ES;
Indirizzi:
CHINOIN Pharmaceut Works Co Ltd, H-1045 Budapest, Hungary CHINOIN Pharmaceut Works Co Ltd Budapest Hungary H-1045 udapest, Hungary Hungarian Acad Sci, Inst Expt Med, H-1083 Budapest, Hungary Hungarian AcadSci Budapest Hungary H-1083 Med, H-1083 Budapest, Hungary
Titolo Testata:
RESTORATIVE NEUROLOGY AND NEUROSCIENCE
fascicolo: 1-2, volume: 13, anno: 1998,
pagine: 41 - 57
SICI:
0922-6028(199810)13:1-2<41:2AA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; GLUTAMATE-RECEPTOR ANTAGONISTS; NON-NMDA RECEPTORS; RAT SPINAL-CORD; H-3 NOREPINEPHRINE RELEASE; AMINO-ACID ANTAGONISTS; CULTURED HIPPOCAMPAL-NEURONS; GAMMA-AMINOBUTYRIC-ACID; KAINATE RECEPTOR; GYKI 52466;
Keywords:
GYKI 52466; epilepsy; spasticity; pain disorders; neuroprotection; neurodegenerative disorders;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
201
Recensione:
Indirizzi per estratti:
Indirizzo: Tarnawa, I POB 110, H-1325 Budapest, Hungary POB 110 Budapest Hungary H-1325 110, H-1325 Budapest, Hungary
Citazione:
I. Tarnawa e E.S. Vizi, "2,3-Benzodiazepine AMPA antagonists", REST NEUROL, 13(1-2), 1998, pp. 41-57

Abstract

The 2,3-benzodiazepine GYKI 52466 (1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine) and its analogues represent a family of selective AMPA antagonists. They modulate AMPA channel functions through an allosteric site on the receptor, which is probably different from the ones involved in the actions of cyclothiazide and aniracetam. These compounds are frequently used as research tools to elucidate glutamate receptor-mediated functions. The most effective members of the family inhibit AMPA-induced currents in the submicromolar range. In addition, they are active at low systemic doses in various in vivo experimental models and also possess a good oral bioavailability. In vitro and in vivo pharmacological results with 2,3-benzodiazepine AMPA antagonists indicate their potential therapeutical value in treating a great variety of central nervous system diseases, of which epilepsy and neurodegenerative disorders are regarded as the most important.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:58:36