Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Segmental vasodilatory effectiveness of inhaled NO in lungs from chronically hypoxic rats
Autore:
Resta, TC; Sanders, TC; Eichinger, MR; Crowley, MR; Walker, BR;
Indirizzi:
Univ131w Mexico, Hlth Sci Ctr, Dept Cell Biol & Physiol, Albuquerque, NM 87 Univ New Mexico Albuquerque NM USA 87131 ol & Physiol, Albuquerque, NM 87 Univ New Mexico, Hlth Sci Ctr, Dept Anesthesiol, Albuquerque, NM 87131 USAUniv New Mexico Albuquerque NM USA 87131 esiol, Albuquerque, NM 87131 USA Univ New Mexico, Hlth Sci Ctr, Dept Pediat, Albuquerque, NM 87131 USA UnivNew Mexico Albuquerque NM USA 87131 ediat, Albuquerque, NM 87131 USA
Titolo Testata:
RESPIRATION PHYSIOLOGY
fascicolo: 2, volume: 114, anno: 1998,
pagine: 161 - 173
SICI:
0034-5687(199811)114:2<161:SVEOIN>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE PULMONARY-DISEASE; GAS-EXCHANGE RESPONSES; NITRIC-OXIDE; HYPERTENSION; INHALATION; CIRCULATION; ARTERIES; NEWBORN; ALTER;
Keywords:
blood flow, pulmonary, NO; hypertension, pulmonary, NO; hypoxia, chronic, effect of NO; mammals, rat; mediators, NO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Resta, TC UnivE,ew Mexico, Hlth Sci Ctr, Dept Cell Biol & Physiol, 915 Camino Salud N Univ New Mexico 915 Camino Salud NE Albuquerque NM USA 87131 d N
Citazione:
T.C. Resta et al., "Segmental vasodilatory effectiveness of inhaled NO in lungs from chronically hypoxic rats", RESP PHYSL, 114(2), 1998, pp. 161-173

Abstract

Inhaled nitric oxide (iNO) is being used to treat pulmonary hypertension in a variety of chronic lung diseases associated with pulmonary vascular remodeling. We hypothesized that chronic hypoxia (CH)-induced vascular remodeling decreases the vasodilatory effectiveness of iNO due to a thickened diffusional barrier. We therefore examined segmental vasodilatory responses to iNO in U-46619-constricted lungs isolated from control and CH (4 weeks at 0.5 atm) rats using double occlusion technique. We further measured lung fluid Bur and vascular wall thickness in lungs from each group to provide an index of vascular permeability and vascular remodeling, respectively. CH wasassociated with decreased venous, but not arterial, responsiveness to iNO in saline-perfused lungs. In addition, the presence of red blood cells (RBC) within the perfusate greatly reduced venodilation in both groups of lungs, indicating that venous responsiveness to iNO in saline-perfused lungs is largely dependent upon transport of NO from an upstream site. In contrast, WBC had no effect on arterial dilation in control lungs, but attenuated arterial dilation to iNO in lungs from CH rats. Finally, fluid flux and arterial wall thickness were greater in lungs from CH rats. We conclude that arterial remodeling associated with CH may limit venous dilation to iNO. Furthermore, the decreased arterial responsiveness to iNO following CH is consistent with extravasation of hemoglobin within the arterial vasculature. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 15:37:57