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Titolo:
Preparation and characterization of poly(D,L-lactide-co-ethylene methyl phosphate)
Autore:
Wen, J; Zhuo, RX;
Indirizzi:
Wuhan Univ, Dept Chem, State Educ Dept China, Lab Biomed Polymer Mat, Wuhan Wuhan Univ Wuhan Peoples R China 430072 a, Lab Biomed Polymer Mat, Wuhan
Titolo Testata:
POLYMER INTERNATIONAL
fascicolo: 4, volume: 47, anno: 1998,
pagine: 503 - 509
SICI:
0959-8103(199812)47:4<503:PACOPM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHORUS-CONTAINING POLYMERS; BIODEGRADABLE POLYMERS; EPSILON-CAPROLACTONE; L-LACTIDE; D,L-LACTIDE; COPOLYMERS; ISOCYANATES; ACID;
Keywords:
poly(D,L-lactide-co-ethylene methyl phosphate); hydrophilicity; polymer hydrolysis; pendant chain functionality; drug delivery system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Zhuo, RX Wuhan Univ, Dept Chem, State Educ Dept China, Lab Biomed Polymer Mat, Wuhan Wuhan Univ Wuhan Peoples R China 430072 omed Polymer Mat, Wuhan
Citazione:
J. Wen e R.X. Zhuo, "Preparation and characterization of poly(D,L-lactide-co-ethylene methyl phosphate)", POLYM INT, 47(4), 1998, pp. 503-509

Abstract

Poly(D,L-lactide-co-ethylene methyl phosphate) was synthesized by ring-opening polymerization of D,L-lactide (D,L-LA) and ethylene methyl phosphate (EMP) in bulk with Al((OPr)-Pr-i)(3) as initiator. The influence of reactionconditions such as polymerization time, polymerization temperature and initiator concentration on the yield and molecular weight were investigated. The reactivity ratios of the two monomers were determined by the Kelen-Tudosmethod. The homogeneous phase of the copolymer was confirmed by differential scanning calorimetry (DSC), wide-angle X-ray diffraction (WAXD) and scanning electron microscopy (SEM). DSC data showed that the glass transition temperature of the copolymers increased with the increase of their LA content, which is in agreement with the Fox equation. Water absorption at room temperature was used to evaluate the hydrophilicity of the copolymers. As expected, the hydrophilicity of the copolymer increased with the increase of EMP fraction therein. Copolymer hydrolysis was carried out in DMSO-d(6)/D2O,in the presence of trifluoroacetic acid; it was monitored by H-1 NMR, the data suggesting that side-chain cleavage proceeded faster than main-chain cleavage, and the hydrolysis of the main chain was faster than that of poly(D,L-lactide). These materials show potential use in drug delivery systems. (C) 1998 Society of Chemical Industry.

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Documento generato il 15/07/20 alle ore 04:47:17