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Titolo:
Effects of neonatal naltrindole treatment on antinociceptive and behavioral responses to mu, and kappa agonists in rats
Autore:
Fernandez, B; Antelo, MT; Kitchen, I; Viveros, MP;
Indirizzi:
Univ Complutense, Fac Biol, Dept Biol Anim 2, E-28040 Madrid, Spain Univ Complutense Madrid Spain E-28040 Biol Anim 2, E-28040 Madrid, Spain Univglandey, Sch Biol Sci, Pharmacol Res Grp, Guildford GU2 5XH, Surrey, En Univ Surrey Guildford Surrey England GU2 5XH uildford GU2 5XH, Surrey, En
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 1, volume: 62, anno: 1999,
pagine: 145 - 149
SICI:
0091-3057(199901)62:1<145:EONNTO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPIOID RECEPTOR ANTAGONIST; MEDIATED ANTINOCICEPTION; SEXUAL ISOLATION; DELTA-AGONISTS; BINDING-SITES; MORPHINE; BRAIN; STIMULATION; OPIATE; POTENTIATION;
Keywords:
neonatal rats; naltrindole; alfentanil; CI-977; antinociception; open field;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Viveros, MP Univ Complutense, Fac Biol, Dept Biol Anim 2, E-28040 Madrid, Spain Univ Complutense Madrid Spain E-28040 E-28040 Madrid, Spain
Citazione:
B. Fernandez et al., "Effects of neonatal naltrindole treatment on antinociceptive and behavioral responses to mu, and kappa agonists in rats", PHARM BIO B, 62(1), 1999, pp. 145-149

Abstract

The effects of a daily injection of the delta selective opioid antagonist naltrindole (1 mg/kg), from birth to postnatal day 19, on antinociceptive and behavioral responses to the mu selective agonist alfentanil (65 mu g/kg)and the kappa selective agonist CI-977 (50 mu g/kg) in 20-day-old male rats were investigated. Antinociception was assessed using the tail immersion test and behavioral testing was performed by employing an open field. The functional blockade of the delta receptor by naltrindole blocked the antinociceptive response to alfentanil but did not affect the antinociception induced by CI-977. The effects of alfentanil (increased exploration) and CI-977(a marked hypoactivity) in the open field were not modified by neonatal naltrindole treatment. The results suggest a functional interaction between delta and mu receptors in the postnatal period but not between delta and kappa receptors. The data also suggest differences in the delta and mu receptors interacting in the modulation of antinociception and those involved in behavioral responses in the open field. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:37:32