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Titolo:
Possible involvement of a sigma receptor subtype in the neck dystonia in rats
Autore:
Nakazawa, M; Kobayashi, T; Matsuno, K; Mita, S;
Indirizzi:
Santen Pharmaceut Co Ltd, Cent Res Labs, Osaka 5338651, Japan Santen Pharmaceut Co Ltd Osaka Japan 5338651 Labs, Osaka 5338651, Japan
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 1, volume: 62, anno: 1999,
pagine: 123 - 126
SICI:
0091-3057(199901)62:1<123:PIOASR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR ACETYLCHOLINE LEVEL; FRONTAL-CORTEX; BINDING-SITES; AGONIST; LIGANDS; SA4503; BRAIN; DRUGS; CLASSIFICATION; PHENCYCLIDINE;
Keywords:
sigma(1) receptor subtype; sigma(2) receptor subtype; neck dystonia; red nucleus; SA4503; DTG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Matsuno, K Santen Pharmaceut Co Ltd, Cent Res Labs, 3-9-19 Shimoshinjo, Osaka 5338651, Santen Pharmaceut Co Ltd 3-9-19 Shimoshinjo Osaka Japan 5338651
Citazione:
M. Nakazawa et al., "Possible involvement of a sigma receptor subtype in the neck dystonia in rats", PHARM BIO B, 62(1), 1999, pp. 123-126

Abstract

To clarify which subtype of a receptors is involved in the a receptor-mediated neck dystonia in rats, we examined whether 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride (SA4503), a selective sigma(1)receptor agonist, and 1,3-di-(2-tolyl)guanidine (DTG), a sigma(1) and sigma(2) receptor agonist, induce neck dystonia in rats. Microinjection of SA4503 into the red nucleus of rat brain scarcely produced neck dystonia at theconcentration of 10 nmol/0.5 mu l. On the contrary, DTG produced significant dystonia at a concentrations of more than 5 nmol/0.5 mu l. These resultsindicate that the at receptor subtype, but not sigma(1) receptor subtype, may play an important role in the sigma receptor-mediated neck dystonia in rats. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:45:51