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Titolo:
Lymphocyte ectoenzymes in childhood idiopathic nephrotic syndrome
Autore:
Stefanovic, V; Golubovic, E; Vlahovic, P; Mitic-Zlatkovic, M;
Indirizzi:
Fac Med, Inst Nephrol & Hemodialysis, Nis, Yugoslavia Fac Med Nis Yugoslavia ed, Inst Nephrol & Hemodialysis, Nis, Yugoslavia
Titolo Testata:
PEDIATRIC NEPHROLOGY
fascicolo: 9, volume: 12, anno: 1998,
pagine: 755 - 760
SICI:
0931-041X(199811)12:9<755:LEICIN>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNE-RESPONSE SUPPRESSOR; DIPEPTIDYL PEPTIDASE-IV; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; ALKALINE PHOSPHODIESTERASE-I; CULTURED MESANGIAL CELLS; ECTO-5'-NUCLEOTIDASE ACTIVITY; MONONUCLEAR-CELLS; GLOMERULAR CELLS; INTERFERON; EXPRESSION;
Keywords:
idiopathic nephrotic syndrome; minimal change disease; focal segmental glomerulosclerosis; lymphocyte ectoenzymes; dipeptidylpeptidase IV; alkaline phosphodiesterase I; concanavalin A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Stefanovic, V Fac Med, Inst Nephrol & Hemodialysis, Nis, Yugoslavia Fac Med Nis Yugoslavia ol & Hemodialysis, Nis, Yugoslavia
Citazione:
V. Stefanovic et al., "Lymphocyte ectoenzymes in childhood idiopathic nephrotic syndrome", PED NEPHROL, 12(9), 1998, pp. 755-760

Abstract

Lymphocyte ectoenzymes with immunomodulatory function were investigated in11 children with minimal change disease (MCD), 9 with primary focal segmental glomerulosclerosis (FSGS), and 17 age- and sex-matched healthy children. Basal, concanavalin A (Con A)-, and pokeweed mitogen (PWM)-stimulated lymphocyte ecto-5'-nucleotidase (5'-Nu), dipeptidyl peptidase IV (DPP IV), andalkaline phosphodiesterase I (APD) activities were determined. In MCD relapse ecto-APD activity of unstimulated lymphocytes was higher than controls. Ecto-APD of Con A-stimulated lymphocytes was below controls (23.0, range 7.2-48.7 nmol/min per 10(6) lymphocytes) in all active MCD (18.7, range 7.6-32.6), during corticosteroid treatment (14.6, range 4.5-54), and in remission (13.1, range 6.1-19.6), but was significant only in remission. Con A-stimulated DPP IV was significantly lower from controls (53.8, range 19.3-85.7nmol/min per 106 lymphocytes) in all active MCD (38.1, range 10.8-82.1), during treatment (37.5, range 20.2-58.7), and in remission (39.4, range 24.3-69.6). In FSGS, unstimulated lymphocyte ecto-APD activity was greater thancontrols. However, Con A-stimulated lymphocyte ecto-APD and DPP IV activities were not significantly different from controls. Con A stimulation of lymphocyte ecto-APD and DPP IV activity was significantly reduced in MCD relapse and in remission, but not in FSGS. Basal, Con A-, and PWM-stimulated ecto-5'-Nu in MCD and FSGS were not different from controls. These results suggest a role for abnormal T cell function in MCD but not in FSGS. The difference in mitogen-stimulated expression of these ectoenzymes suggests a different pathogenesis of childhood MCD and primary FSGS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:07:37