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Titolo:
The molecular biology of polycystic kidney disease
Autore:
Murcia, NS; Woychik, RP; Avner, ED;
Indirizzi:
Rainbow Babies & Childrens Hosp, Dept Pediat, Cleveland, OH 44106 USA Rainbow Babies & Childrens Hosp Cleveland OH USA 44106 land, OH 44106 USA
Titolo Testata:
PEDIATRIC NEPHROLOGY
fascicolo: 9, volume: 12, anno: 1998,
pagine: 721 - 726
SICI:
0931-041X(199811)12:9<721:TMBOPK>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTOR; TETRATRICOPEPTIDE REPEAT-DOMAIN; PEROXISOMAL TARGETING SIGNAL; POLYCYSTIC-KIDNEY-DISEASE-1 PKD1; SACCHAROMYCES-CEREVISIAE; PROTOONCOGENE EXPRESSION; NONSENSE MUTATION; MESSENGER-RNA; CPK MOUSE; GENE;
Keywords:
polycystic kidney disease; polycystin; PKD1; PKD2; autosomal recessive polycystic kidney disease orpk; Tg737; epidermal growth factor receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Avner, ED Rainbow03,bies & Childrens Hosp, Dept Pediat, 11100 Euclid Ave,Mail Stop 60 Rainbow Babies & Childrens Hosp 11100 Euclid Ave,Mail Stop 6003Cleveland OH USA 44106
Citazione:
N.S. Murcia et al., "The molecular biology of polycystic kidney disease", PED NEPHROL, 12(9), 1998, pp. 721-726

Abstract

In recent years there have been a number of developments in polycystic kidney disease (PKD) research. The genes associated with the predominant formsof autosomal dominant PKD have been cloned, and the gene associated with amouse model for autosomal recessive PKD has been identified and characterized. Other studies have yielded new information regarding the role of the epidermal growth factor receptor gene in promoting renal cyst formation. In this review article we summarize recent pulished data on the molecular genetics of autosomal dominant and autosomal recessive PKD and provide a working model of how multiple genes participate in the PKD disease pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:18:57