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Titolo:
Immunological studies of the placenta in maternal connective tissue disease
Autore:
Ackerman, J; Gonzalez, EF; Gilbert-Barness, E;
Indirizzi:
Univ S Florida, Dept Pathol & Lab Med, Tampa, FL USA Univ S Florida TampaFL USA lorida, Dept Pathol & Lab Med, Tampa, FL USA Univ Wisconsin, Sch Med, Dept Pathol & Lab Med, Madison, WI USA Univ Wisconsin Madison WI USA ed, Dept Pathol & Lab Med, Madison, WI USA
Titolo Testata:
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
fascicolo: 1, volume: 2, anno: 1999,
pagine: 19 - 24
SICI:
1093-5266(199901/02)2:1<19:ISOTPI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; ANTIPHOSPHOLIPID ANTIBODIES; PREGNANCY LOSS; DECIDUAL VASCULOPATHY; FETAL DEATH; ANTICOAGULANT;
Keywords:
placenta; connective tissue disorders; fetus; lupus anticoagulant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Gilbert-Barness, E Tampa Gen Hosp, Dept Pathol, POB 1289, Tampa, FL 33601 USA Tampa Gen Hosp POB 1289 Tampa FL USA 33601 FL 33601 USA
Citazione:
J. Ackerman et al., "Immunological studies of the placenta in maternal connective tissue disease", PEDIATR D P, 2(1), 1999, pp. 19-24

Abstract

Maternal connective tissue disease is an important cause of second-trimester fetal loss. In order to assess the pathological changes in the placenta in maternal connective tissue disease, we reviewed the clinical histories and performed histologic and immunofluorescence studies on nine placentas: five from mothers with systemic lupus erythematosus (SLE), two from mothers with mixed connective tissue disease (MCTD), one from a mother with rheumatoid arthritis (RA), and one from a mother without prior known connective tissue disease. Excessive intervillous fibrin deposition and infarction were noted in all cases. Immunofluorescent and immunoperoxidase studies showed deposits of fibrinogen, IgG, IgM, IgA, and complement 3 (C3) localized to the trophoblast basement membrane (TBM). Electron microscopy documented thickening of the trophoblast basal lamina in three SLE placentas examined. The use of immunofluorescence may be enhanced further if antitrophoblast antibodies can be linked to placental compromise.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 04:01:07