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Titolo:
QUALITATIVE MAGNETIC-RESONANCE-IMAGING FINDINGS IN GERIATRIC DEPRESSION - POSSIBLE LINK BETWEEN LATER-ONSET DEPRESSION AND ALZHEIMERS-DISEASE
Autore:
GREENWALD BS; KRAMERGINSBERG E; BOGERTS B; ASHTARI M; AUPPERLE P; WU H; ALLEN L; ZEMAN D; PATEL M;
Indirizzi:
LONG ISL JEWISH MED CTR,HILLSIDE HOSP,DIV GERIATR PSYCHIAT,DIV PSYCHIAT,RES BLDG,75-579 263RD ST GLEN OAKS NY 11004 LONG ISL JEWISH MED CTR,HILLSIDE HOSP,BRAIN MORPHOMETRY & IMAGE ANAL CTR,DIV PSYCHIAT GLEN OAKS NY 11004 ALBERT EINSTEIN COLL MED BRONX NY 10467 LONG ISL JEWISH MED CTR,DEPT RADIOL GLEN OAKS NY 11004
Titolo Testata:
Psychological medicine
fascicolo: 2, volume: 27, anno: 1997,
pagine: 421 - 431
SICI:
0033-2917(1997)27:2<421:QMFIGD>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; MEDIAL TEMPORAL-LOBE; LATE-LIFE DEPRESSION; CEREBRAL BLOOD-FLOW; MINI-MENTAL STATE; COMPUTED-TOMOGRAPHY; ELDERLY DEPRESSIVES; MAJOR DEPRESSION; MOOD DISORDERS; FOLLOW-UP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
77
Recensione:
Indirizzi per estratti:
Citazione:
B.S. Greenwald et al., "QUALITATIVE MAGNETIC-RESONANCE-IMAGING FINDINGS IN GERIATRIC DEPRESSION - POSSIBLE LINK BETWEEN LATER-ONSET DEPRESSION AND ALZHEIMERS-DISEASE", Psychological medicine, 27(2), 1997, pp. 421-431

Abstract

Background. Several clinical and neuroimaging investigations support the notion that underlying brain changes may relate to depression in older patients, especially those with a later-age initial episode. However uncertainty still exists about diagnostic and pathogenic significance of structural brain abnormalities in aged depressives, in part because many studies lack all-elderly and age-similar normal comparison populations. Methods. Brain morphology of elderly depressives (N = 30) and normal controls (N = 36) was compared by assessing magnetic resonance imaging (MRI) brain scans with qualitative criteria-based scales. Ratings included lateral and third ventricle enlargement, and cortical, medial temporal, and caudate atrophy. Results. Significant differences between depressed and control groups were not demonstrated. Later-onset depressives had significantly more left medial temporal and left caudate atrophy than early-onset counterparts of similar age. Medial temporal atrophy significantly correlated with cognitive impairment andwas not related to physical illness, Depressives with medial temporalatrophy (N = 7) were older and had later age at onset of depression than those without such changes. Cerebrovascular disease risk factors did not predict MRI abnormalities, Conclusions. Results indicate non-specificity and lack of homogeneity of qualitatively measured structuralbrain changes in geriatric depression, but suggest that pathology of specific, lateralized brain regions may be implicated in some later-onset patients, The relationship between medial temporal atrophy and late-onset depression raises the possibility that such patients may suffer from as-yet undeclared Alzheimer's disease, Lack of association between cerebrovascular disease risk factors and brain changes suggests other pathophysiological contributions.

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Documento generato il 30/03/20 alle ore 00:35:09