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Titolo:
Angiogenesis during tumor progression in the oral cavity is related to reduced apoptosis and high tumor cell proliferation
Autore:
Ravi, D; Ramadas, K; Mathew, BS; Nalinakumari, KR; Nair, MK; Pillai, MR;
Indirizzi:
Reg Canc Ctr, Div Lab Med, Trivandrum 695011, Kerala, India Reg Canc Ctr Trivandrum Kerala India 695011 vandrum 695011, Kerala, India Reg Canc Ctr, Div Radiat Oncol, Trivandrum 695011, Kerala, India Reg Canc Ctr Trivandrum Kerala India 695011 vandrum 695011, Kerala, India Reg Canc Ctr, Div Dent Surg, Trivandrum 695011, Kerala, India Reg Canc Ctr Trivandrum Kerala India 695011 vandrum 695011, Kerala, India
Titolo Testata:
ORAL ONCOLOGY
fascicolo: 6, volume: 34, anno: 1998,
pagine: 543 - 548
SICI:
1368-8375(199811)34:6<543:ADTPIT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
P53; EXPRESSION; CARCINOMA; THROMBOSPONDIN-1; MECHANISMS; METASTASIS; NEOPLASIA; INDUCTION; LESIONS; HYPOXIA;
Keywords:
angiogenesis; apoptosis; proliferation; oral cancer; tumor progression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Pillai, MR Reg Canc Ctr, Div Lab Med, Trivandrum 695011, Kerala, India RegCanc Ctr Trivandrum Kerala India 695011 011, Kerala, India
Citazione:
D. Ravi et al., "Angiogenesis during tumor progression in the oral cavity is related to reduced apoptosis and high tumor cell proliferation", ORAL ONCOL, 34(6), 1998, pp. 543-548

Abstract

Angiogenesis, the growth of new blood vessels, is believed to aid turner progression and metastasis. Tumor progression is also influenced by the extent of proliferation and apoptosis. This study, therefore, analyzed in lesions of the oral cavity, the significance of angiogenesis in relation to apoptosis, expression of apoptosis regulatory p53, bar and bcl-2 proteins as well as tissue proliferation defined by cyclin D1 expression. Results from this study suggest that angiogenesis increases as histological abnormality increases in the oral mucosa. The expression of apoptosis regulatory proteinsalso appears to be altered in a histologically dependent manner. The correlation seen between CD34 expression, cyclin D1 and TUNEL reactive cells suggests that increased angiogenesis, decreased apoptosis and deregulated proliferation occur simultaneously during tumor progression in the oral mucosa. Presence of a mutant p53, increased bcl-2 expression and altered bar expression are also involved in this complex process. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 00:13:44