Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Amiloride and vertebrate gustatory responses to NaCl
Autore:
Halpern, BP;
Indirizzi:
Cornell Univ, Dept Psychol, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 Univ, Dept Psychol, Ithaca, NY 14853 USA Cornell Univ, Div Biol Sci, Neurobiol & Behav Sect, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 obiol & Behav Sect, Ithaca, NY 14853 USA Monell Chem Senses Ctr, Philadelphia, PA USA Monell Chem Senses Ctr Philadelphia PA USA ses Ctr, Philadelphia, PA USA
Titolo Testata:
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
fascicolo: 1, volume: 23, anno: 1998,
pagine: 5 - 47
SICI:
0149-7634(199811)23:1<5:AAVGRT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSITIVE NA+ CHANNELS; TASTE NERVE RESPONSES; CHORDA TYMPANI NERVE; CANINE LINGUAL EPITHELIUM; SODIUM-CHLORIDE; ION-TRANSPORT; BITTER TASTE; SALT TASTE; MOLECULAR MECHANISMS; SALIVARY-GLANDS;
Keywords:
taste; salt; NaCl; KCl; amiloride; neurophysiology; behavior; psychophysics;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
128
Recensione:
Indirizzi per estratti:
Indirizzo: Halpern, BP Cornell Univ, Dept Psychol, Ithaca, NY 14853 USA Cornell UnivIthaca NY USA 14853 sychol, Ithaca, NY 14853 USA
Citazione:
B.P. Halpern, "Amiloride and vertebrate gustatory responses to NaCl", NEUROSCI B, 23(1), 1998, pp. 5-47

Abstract

Amiloride at greater than or equal to 1 mu M may block epithelial Naf channels without affecting other cellular mechanisms, and attenuates gustatory responses to Lingual NaCl from the chorda tympani nerves (CT) of gerbil, hamster, rhesus monkey, and several strains of laboratory rat and mouse, and from glossopharyngeally innervated frog taste-receptor cells; at 5 mu M to 50 mu M, also from Wistar rat and mongrel dog CT. Affected units responded more to NaCl than to KCI. Suppression of CT responses to KCl, HCl, NH4Cl, or saccharides also occurred in some mammals, but amiloride did not elicit responses. Taste-dependent behaviors towards NaCl or KCI were altered. DBA and 129/J laboratory mice, and mudpuppy, were unaffected by amiloride. In humans, 10 mu M amiloride both produced taste reports and reduced total intensity of NaCl and LiCl by 15-20%. NaCl and LiCl sourness, and KCl and QHCl bitterness declined, but saltiness generally did not change. Effects on sweetness were inconsistent. Amiloride-sensitive gustatory mechanisms were prominent in some mammals, were not necessary for responses to NaCl, and were of minor importance for human taste. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 03:19:19