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Titolo:
High and low responders to novelty: Effects of a catecholamine synthesis inhibitor on novelty-induced changes in behaviour and release of accumbal dopamine
Autore:
Saigusa, T; Tuinstra, T; Koshikawa, N; Cools, AR;
Indirizzi:
Nihon Univ, Sch Dent, Dept Pharmacol, Chiyoda Ku, Tokyo 1018310, Japan Nihon Univ Tokyo Japan 1018310 armacol, Chiyoda Ku, Tokyo 1018310, Japan Univ Nijmegen, Dept Psychoneuropharmacol, Nijmegen, Netherlands Univ Nijmegen Nijmegen Netherlands europharmacol, Nijmegen, Netherlands
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 88, anno: 1999,
pagine: 1153 - 1163
SICI:
0306-4522(199902)88:4<1153:HALRTN>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT NUCLEUS-ACCUMBENS; STIMULUS REWARD ASSOCIATIONS; PITUITARY-ADRENAL ACTIVITY; STRESS-INDUCED INCREASE; FREELY MOVING RATS; VENTRAL STRIATUM; WISTAR RATS; INDIVIDUAL VULNERABILITY; 6-OHDA LESIONS; MICRODIALYSIS;
Keywords:
novelty; dopamine; nucleus accumbens; individual difference; alpha-methyl-p-tyrosine; microdialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Saigusa, T Nihonokyov, Sch Dent, Dept Pharmacol, Chiyoda Ku, 1-8-13 Kanda Surugadai, T Nihon Univ 1-8-13 Kanda Surugadai Tokyo Japan 1018310 gadai, T
Citazione:
T. Saigusa et al., "High and low responders to novelty: Effects of a catecholamine synthesis inhibitor on novelty-induced changes in behaviour and release of accumbal dopamine", NEUROSCIENC, 88(4), 1999, pp. 1153-1163

Abstract

The purpose of the present study was two-fold: (i) to investigate to what extent novelty, i.e. a novel cage with slightly larger dimensions than the home cage and lacking the floor covering that was originally present, produced behavioural effects in high responders to novelty and low responders tonovelty that could be correlated with the extracellular amount of accumbaldopamine, using the microdialysis technique, and (ii) to establish the ability of the catecholamine synthesis inhibitor a-methyl-p-tyrosine to inhibit the novelty-induced responses in high and low responders. The difference in the behavioural response to novelty between the high and low responders was limited to walking, which lasted significantly longer in high responders than in low responders. The novelty-induced increase in extracellular concentration of accumbal dopamine was significantly greater in high responders than in low responders; moreover, the shape of the growth curves differedbetween high and low responders. The behavioural changes did not correlatewith the neurochemical effects, which outlasted the duration of the novelty-induced behavioural arousal. II is hypothesized that this long-lasting increase in accumbal dopamine produces "adaptive changes" that help and/or allow the animal to incorporate knowledge about the condition that it experienced. When the nucleus accumbens was perfused with alpha-methyl-p-tyrosine for a period of 40 min, given at the same time as the transfer of the rat to the novel cage, it reduced the novelty-induced increase in walking in thehigh responders, but did not alter the novelty induced behaviour of low responders. Finally, alpha-methyl-p-tyrosine reduced the novelty-induced increase in the release of accumbal dopamine in high responders, but enhanced it in low responders. The present neurochemical data are discussed in view of the outcome of earlier reported pharmaco-behavioural studies on the neurochemical slate of the nucleus accumbens of non-challenged versus challenged high and low responders. It is hypothesized that, in the high responder, exposure to novelty enhances the release of accumbal dopamine from reserpine-resistant, alpha-methyl-p-tyrosine-sensitive pools that are under the stimulatory control of beta-adrenergic receptors in the nucleus accumbens, and that, in the low responder, exposure to novelty enhances the release of accumbal dopamine from reserpine-sensitive, alpha-methyl-p-tyrosine-resistant pools that are underthe inhibitory control of alpha-adrenergic receptors in the nucleus accumbens. (C) 1998 IBRO. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 04:37:34