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Titolo:
Visual input regulates the expression of basic fibroblast growth factor and its receptor
Autore:
Gomez-Pinilla, F; Choi, J; Ryba, EA;
Indirizzi:
Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 ng & Dementia, Irvine, CA 92697 USA Univ Calif Irvine, Dept Neurol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 , Dept Neurol, Irvine, CA 92697 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 88, anno: 1999,
pagine: 1051 - 1058
SICI:
0306-4522(199902)88:4<1051:VIRTEO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR MESSENGER-RNA; MONOCULAR DEPRIVATION; NEUROTROPHIC FACTOR; NERVOUS-SYSTEM; FGF RECEPTOR; RAT-BRAIN; IN-VIVO; CORTEX; NEURONS; SEIZURES;
Keywords:
environmental enrichment; astrocytes; light; darkness; neural activity; occipital cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Gomez-Pinilla, F Univ Calif Los Angeles, Dept Physiol Sci, Box 951527, LosAngeles, CA 90095 Univ Calif Los Angeles Box 951527 Los Angeles CA USA 90095
Citazione:
F. Gomez-Pinilla et al., "Visual input regulates the expression of basic fibroblast growth factor and its receptor", NEUROSCIENC, 88(4), 1999, pp. 1051-1058

Abstract

Emerging evidence indicates that the expression of trophic factors in the brain is regulated in an activity-dependent manner, which suggests an involvement of trophic factors in events controlled by input activity. We have investigated the possibility that visual sensory input impacts the expression of basic fibroblast growth factor and its receptor in the brain. Rats were maintained for seven days in darkness and then re-exposed to normal illumination for 0, 1, 3 or 6 h. We assessed relative levels of basic fibroblastgrowth factor and fibroblast growth factor receptor messenger RNAs using nuclease protection assays, and examined possible changes in the phenotypic expression of basic fibroblast growth factor and its receptor using immunohistochemistry. There was a significant decrease in levels of basic fibroblast growth factor and fibroblast growth factor receptor messenger RNAs as a result of dark rearing, and levels of messenger RNAs increased progressively with light re-exposure. Changes in messenger RNAs were observed primarilyin the cerebral cortex (caudal portion) and were accompanied by alterations in the staining intensity and density of cells exhibiting basic fibroblast growth factor and fibroblast growth factor receptor phenotypes. Regulation of the basic fibroblast growth factor system by sensory input suggests that basic fibroblast growth factor, and perhaps other trophic factors, are mediators of the effects of experience on the structure and function of the CNS. (C) 1998 IBRO. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:09:46