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Titolo:
Kainate-induced retina amacrine-like cell damage is mediated by AMPA receptors
Autore:
Ferreira, IL; Duarte, CB; Carvalho, AP;
Indirizzi:
Univ Coimbra, Dept Zool, Ctr Neurosci Coimbra, P-3000 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3000 i Coimbra, P-3000 Coimbra, Portugal
Titolo Testata:
NEUROREPORT
fascicolo: 15, volume: 9, anno: 1998,
pagine: 3471 - 3475
SICI:
0959-4965(19981026)9:15<3471:KRACDI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBELLAR GRANULE NEURONS; AMINO-ACID RECEPTORS; CHICK RETINA; GLUTAMATE RECEPTORS; H-3 GABA; NEUROTOXICITY; AGONISTS; RELEASE; DESENSITIZATION; CYCLOTHIAZIDE;
Keywords:
AMPA; Ca2+ uptake; cyclothiazide; domoate; excitotoxicity; kainate; LY 303070; retina cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Ferreira, IL Univ Coimbra, Dept Zool, Ctr Neurosci Coimbra, P-3000 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3000 3000 Coimbra, Portugal
Citazione:
I.L. Ferreira et al., "Kainate-induced retina amacrine-like cell damage is mediated by AMPA receptors", NEUROREPORT, 9(15), 1998, pp. 3471-3475

Abstract

WE investigated the effect of domoate, kainate and AMPA on Ca-45(2+) uptake and on metabolic activity of cultured chick amacrine-like cells, as measured by reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). Domoate and kainate stimulated Ca-45(2+) uptake and decreased MTT reduction, in a LY 303070-sensitive manner. AMPA caused a small increase on Ca-45(2+) uptake, but it was without effect on MTT reduction. AMPA reduced both the Ca-45(2+) entry and neurotoxicity induced by kainate, and cyclothiazide enhanced both the Ca-45(2+) entry and neurotoxicity induced by AMPA. The results indicate that the AMPA receptors are the non-NMDA glutamate receptors involved in excitotoxicity. (C) 1998 Lippincott Williams & Wilkins.

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Documento generato il 06/07/20 alle ore 04:31:53