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Titolo:
Induction of neuropeptide Y expression in dorsomedial hypothalamus of diet-induced obese mice
Autore:
Guan, XM; Yu, H; Trumbauer, M; Frazier, E; Van der Ploeg, LHT; Chen, H;
Indirizzi:
Merck Res Labs, Dept Obes Res, Rahway, NJ 07065 USA Merck Res Labs RahwayNJ USA 07065 s, Dept Obes Res, Rahway, NJ 07065 USA
Titolo Testata:
NEUROREPORT
fascicolo: 15, volume: 9, anno: 1998,
pagine: 3415 - 3419
SICI:
0959-4965(19981026)9:15<3415:IONYEI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-EXPRESSION; ARCUATE NUCLEUS; LEPTIN LEVELS; RAT; RNA; ORGANIZATION; PROJECTIONS; STRAINS; WEIGHT;
Keywords:
agouti-related protein; diet-induced obesity; dorsomedial hypothalamic nucleus; expression; mRNA; neuropeptide Y; pro-opiomelanocortin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Guan, XM Merck Res Labs, Dept Obes Res, POB 2000,R80M-213, Rahway, NJ 07065 USA Merck Res Labs POB 2000,R80M-213 Rahway NJ USA 07065 NJ 07065 USA
Citazione:
X.M. Guan et al., "Induction of neuropeptide Y expression in dorsomedial hypothalamus of diet-induced obese mice", NEUROREPORT, 9(15), 1998, pp. 3415-3419

Abstract

ALTERATIONS of hypothalamic neuropeptide Y(NPY) and melanocortinergic functions in diet-induced obese (DIO) C57BL/6J mice were investigated by in situ hybridization. Compared with controls, the DIO mice displayed a profound induction (similar to 40-fold) of NPY expression in the dorsomedial (DMH) and ventromedial (VMH) hypothalamic nuclei, whereas the level of NPY mRNA inthe arcuate nucleus (ARC) was reduced by 44%. The expression of pro-opiomelanocortin (POMC) and agouti-related protein was not significantly altered in the ARC of obese mice. Both excess body weight gain and altered hypothalamic NPY expression were reversible. We propose that the highly induced NPYexpression in DMH and/or VMH may be a contributing etiological factor for the development of obesity and leptin resistance in the DIO mice. (C) 1998 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:22:04