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Titolo:
Efficacy and safety of oral sildenafil (Viagra) in men with erectile dysfunction caused spinal cord injury
Autore:
Derry, FA; Dinsmore, WW; Fraser, M; Gardner, BP; Glass, CA; Maytom, MC; Smith, MD;
Indirizzi:
Pfizer Cent Res, Sandwich CT13 9NJ, Kent, England Pfizer Cent Res Sandwich Kent England CT13 9NJ ch CT13 9NJ, Kent, England Royal Victoria Hosp, Belfast BT12 6BA, Antrim, North Ireland Royal Victoria Hosp Belfast Antrim North Ireland BT12 6BA , North Ireland Reg Spinal Injury Ctr, Southport, England Reg Spinal Injury Ctr Southport England Injury Ctr, Southport, England
Titolo Testata:
NEUROLOGY
fascicolo: 6, volume: 51, anno: 1998,
pagine: 1629 - 1633
SICI:
0028-3878(199812)51:6<1629:EASOOS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PENILE ERECTION; PHYSIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Maytom, MC Pfizer Cent Res, Ramsgate Rd, Sandwich CT13 9NJ, Kent, England Pfizer Cent Res Ramsgate Rd Sandwich Kent England CT13 9NJ land
Citazione:
F.A. Derry et al., "Efficacy and safety of oral sildenafil (Viagra) in men with erectile dysfunction caused spinal cord injury", NEUROLOGY, 51(6), 1998, pp. 1629-1633

Abstract

Objective: To evaluate the efficacy and safety of 50-mg doses of sildenafil during a 28-day period in patients with erectile dysfunction caused by spinal cord injury (cord level range, T6 through L5). Background: Sildenafil is an orally active, potent, and selective inhibitor of phosphodiesterase type 5, an important regulator of cyclic guanosine monophosphate in the human corpus cavernosum. Methods: To be included in this double-blind, placebo-controlled study, all patients had to be able to achieve at least a partialreflexogenic erectile response to penile vibratory stimulation. The study utilized a single triangular sequential trial design. A total of 27 patients were randomized to receive 50 mg of sildenafil or placebo, taken orally as required (not more than once daily) approximately I hour before sexual activity. Results: After 28 days of treatment, nine of 12 patients (75%) on sildenafil and one of 14 patients (7%) on placebo reported that treatment had improved their erections (p = 0.0043). Furthermore, eight of 12 patients (67%) on sildenafil and two of 13 patients (15%) on placebo indicated that they wished to continue treatment (p = 0.018). A significant improvement insatisfaction with their sex life was reported by patients taking sildenafil (p = 0.012). No patients discontinued treatment due to adverse events. Conclusion: Oral sildenafil, taken as required (not more than once daily), significantly improves the quality of erections and satisfaction with sex life in men with erectile dysfunction caused by a spinal cord injury between T6 and L5.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 04:11:37