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Titolo:
Afferent-specific innervation of two distinct AMPA receptor subtypes on single hippocampal interneurons
Autore:
Toth, K; McBain, CJ;
Indirizzi:
NICHD, Lab Cellular & Mol Neurophysiol, Bethesda, MD 20892 USA NICHD Bethesda MD USA 20892 ar & Mol Neurophysiol, Bethesda, MD 20892 USA
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 7, volume: 1, anno: 1998,
pagine: 572 - 578
SICI:
1097-6256(199811)1:7<572:AIOTDA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG HIPPOCAMPUS; MOSSY FIBER SYNAPSES; GLUTAMATE RECEPTORS; RAT HIPPOCAMPUS; CA2+ PERMEABILITY; SUBUNIT COMPOSITION; KAINATE RECEPTORS; SYNAPTIC TRANSMISSION; INWARD RECTIFICATION; SELECTIVE ANTAGONISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: McBain, CJ NICHD,esda,Cellular & Mol Neurophysiol, Rm 5A72,Bldg 49,49 Convent Dr, Beth NICHD Rm 5A72,Bldg 49,49 Convent Dr Bethesda MD USA 20892 Beth
Citazione:
K. Toth e C.J. McBain, "Afferent-specific innervation of two distinct AMPA receptor subtypes on single hippocampal interneurons", NAT NEUROSC, 1(7), 1998, pp. 572-578

Abstract

Using the polyamine toxin philanthotoxin, which selectively blocks calcium-permeable AMPA receptors, we show that synaptic transmission onto single hippocampal interneurons occurs by afferent-specific activation of philanthotoxin-sensitive and -insensitive AMPA receptors, Calcium-permeable AMPA receptors are found exclusively at synapses from mossy fibers. In contrast, synaptic responses evoked by stimulation of CA3 pyramidal neurons are mediated by calcium-impermeable AMPA receptors. Both pathways converge onto singleinterneurons and can be discriminated with Group II mGluR agonists. Thus, single interneurons target AMPA receptors of different subunit composition to specific postsynaptic sites, providing a mechanism to increase the synapse-specific computational properties of hippocampal interneurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 20:00:43