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Titolo:
P/Q-type voltage/gated calcium channel antibodies in paraneoplastic disorders of the central nervous system
Autore:
Voltz, R; Carpentier, AF; Rosenfeld, MR; Posner, JB; Dalmau, J;
Indirizzi:
Mem Sloan Kettering Canc Ctr, Dept Neurol, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA Cornell Univ, Coll Med, Dept Neurol & Neurosci, New York, NY USA Cornell Univ New York NY USA d, Dept Neurol & Neurosci, New York, NY USA
Titolo Testata:
MUSCLE & NERVE
fascicolo: 1, volume: 22, anno: 1999,
pagine: 119 - 122
SICI:
0148-639X(199901)22:1<119:PVCCAI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
EATON-MYASTHENIC-SYNDROME; CELL LUNG-CARCINOMA; CEREBELLAR DEGENERATION; LAMBERT; IMMUNOGLOBULINS; AUTOANTIBODIES; CANCER;
Keywords:
P/Q-type voltage-gated calcium channel antibodies; paraneoplastic; neurological disorders; anti-Hu; paraneoplastic cerebellar degeneration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Dalmau, J Mem1Sloan Kettering Canc Ctr, Dept Neurol, 1275 York Ave, New York, NY 1002 Mem Sloan Kettering Canc Ctr 1275 York Ave New York NY USA 10021
Citazione:
R. Voltz et al., "P/Q-type voltage/gated calcium channel antibodies in paraneoplastic disorders of the central nervous system", MUSCLE NERV, 22(1), 1999, pp. 119-122

Abstract

Whether P/Q-type voltage-gated calcium channel (VGCC) antibodies are present in the serum of patients with paraneoplastic syndromes other than the Lambert-Eaton myasthenic syndrome (LEMS) and tumors other than small-cell lung cancer (SCLC) is controversial, Using a commercially available radioimmunoprecipitation assay kit, we examined the sera of 93 patients with paraneoplastic syndromes of the central nervous system (CNS), including 27 patientswith paraneoplastic cerebellar degeneration (PCD) associated with tumors other than SCLC and 66 SCLC patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/SN). All PCD sera from patients with tumors other than SCLC were negative for P/Q-type VGCC antibodies. Eight of 66 (12%)SCLC patients with PEM/SN had P/Q-type VGCC antibodies; 4 had LEMS and theother 4 had no symptoms of LEMS or they were overlooked and, therefore, not examined electrophysiologically. In patients with paraneoplastic syndromes of the CNS, the detection of P/Q-type VGCC antibodies supports the diagnosis of LEMS; in our series, only 6% of patients with SCLC and PEM/SN may have had a false positive antibody result, or undiagnosed LEMS. (C) 1999 JohnWiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:48:51