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Titolo:
Prevalence of coronary blood flow reserve abnormalities among patients with nonobstructive coronary artery disease and chest pain
Autore:
Hasdai, D; Holmes, DR; Higano, ST; Burnett, JC; Lerman, A;
Indirizzi:
Mayoochester,ayo Fdn, Div Cardiovasc Dis, Ctr Coronary Physiol & Imaging, R Mayo Clin & Mayo Fdn Rochester MN USA 55905 Coronary Physiol & Imaging, R Mayo5Clin & Mayo Fdn, Div Cardiovasc Dis & Internal Med, Rochester, MN 5590 Mayo Clin & Mayo Fdn Rochester MN USA 55905 ernal Med, Rochester, MN 5590
Titolo Testata:
MAYO CLINIC PROCEEDINGS
fascicolo: 12, volume: 73, anno: 1998,
pagine: 1133 - 1140
SICI:
0025-6196(199812)73:12<1133:POCBFR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TERM FOLLOW-UP; ENDOTHELIUM-DEPENDENT VASODILATION; RISK-FACTORS; MYOCARDIAL PERFUSION; VASOMOTOR RESPONSES; ANGINA-PECTORIS; SYNDROME-X; DYSFUNCTION; ACETYLCHOLINE; ATHEROSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Lerman, A Mayo00lin & Mayo Fdn, Div Cardiovasc Dis, Ctr Coronary Physiol &Imaging, 2 Mayo Clin & Mayo Fdn 200 1st St SW Rochester MN USA 55905 ing, 2
Citazione:
D. Hasdai et al., "Prevalence of coronary blood flow reserve abnormalities among patients with nonobstructive coronary artery disease and chest pain", MAYO CLIN P, 73(12), 1998, pp. 1133-1140

Abstract

Objective: To determine the prevalence of abnormalities in endothelium-dependent and endothelium-independent coronary Bow reserve among patients withnonobstructive coronary artery disease and chest pain. Material and Methods: We studied endothelium-dependent (after infusion of 10(-6) M to 10(-4) M of acetylcholine) and endothelium-independent (after administration of 18 to 36 mu g of adenosine) coronary flow reserve among patients with nonobstructive coronary artery disease and chest pain who were undergoing assessment at Mayo Clinic Rochester. Coronary blood flow was derived from coronary artery diameter assessed by quantitative angiography andDoppler Bow velocities. Results: The cohort consisted of 203 patients (158 female and 45 mate patients), who ranged in age from 17 to 78 years (mean, 51), Most patients (92%) had at least one risk factor for atherosclerosis; a substantial proportion had undergone extensive cardiac and noncardiac evaluation. Whereas 41.5% of the patients had normal coronary Bow reserve, 58.5% had an abnormal response: 11.3% an impaired response to adenosine (flow velocity ratio of 2.5 or less), 29.2% an impaired response to acetylcholine (flow reserve ratio of1.5 or less), and 18% a combined abnormality, No correlation (r(2) = 0.03)was noted between endothelium-dependent and endothelium-independent flow reserve. Conclusion: Most study patients with chest pain and nonobstructive coronary artery disease undergoing coronary vasomotor evaluation had risk factors for coronary artery disease and diverse abnormalities in endothelium-dependent or endothelium-independent coronary flow reserve (or both). These findings underscore the need for a comprehensive assessment.

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Documento generato il 04/07/20 alle ore 20:27:16