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Titolo:
Pulmonary involvement in juvenile systemic lupus erythematosus: a study onlung function in patients asymptomatic for respiratory disease
Autore:
Trapani, S; Camiciottoli, G; Ermini, M; Castellani, W; Falcini, F;
Indirizzi:
Univ Florence, Dept Pediat, Rheumatol Unit, I-50121 Florence, Italy Univ Florence Florence Italy I-50121 matol Unit, I-50121 Florence, Italy Univ Florence, Resp Unit, Dept Clin Pathophysiol, I-50121 Florence, Italy Univ Florence Florence Italy I-50121 thophysiol, I-50121 Florence, Italy
Titolo Testata:
LUPUS
fascicolo: 8, volume: 7, anno: 1998,
pagine: 545 - 550
SICI:
0961-2033(1998)7:8<545:PIIJSL>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHILDREN AGED 4; CHILDHOOD; ANTIBODIES;
Keywords:
systemic lupus erythematosus; childhood; pulmonary function tests;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Trapani, S Aorence,Hosp, Dept Pediat, Rheumatol Unit, Via Luca Giordano 13, I-50132 Fl A Meyer Hosp Via Luca Giordano 13 Florence Italy I-50132 32 Fl
Citazione:
S. Trapani et al., "Pulmonary involvement in juvenile systemic lupus erythematosus: a study onlung function in patients asymptomatic for respiratory disease", LUPUS, 7(8), 1998, pp. 545-550

Abstract

Pleuro-pulmonary involvement has been well recognized in adults affected with systemic lupus erythematosus (SLE), but few studies have been carried out in children. A longitudinal study on a group of 15 children affected with juvenile SLE (JSLE), asymptomatic for lung disease, was performed and theprevalence and the features of respiratory function alterations, over a period of 12 months, were analysed. Moreover, a possible correlation between any pulmonary function test (PFT) and disease duration, disease activity, visceral involvement and immunological pattern was evaluated. At baseline, asignificant functional lung impairment was present in 40% of patients, with a significantly reduced FVC, V-A and DLCO in 26% of them; in 60% of patients at 6 months and in 33% of patients at 12 months. At 6 and 12 months, our data did not show any significant modification in PFTs and the restrictive pattern, observed at baseline, remained unchanged. No correlation betweenaltered PFTs and disease duration, activity and/or immunological findings was found. At baseline, the presence of neurological involvement was the only extra-pulmonary feature correlated to reduced FVC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:45:15