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Titolo:
History and classification of human leukemia-lymphoma cell lines
Autore:
Drexler, HG; Minowada, J;
Indirizzi:
DSMZ,tures,n Collect Microorgan & Cell Cultures, Dept Human & Anim Cell Cul DSMZ Braunschweig Germany D-38124 l Cultures, Dept Human & Anim Cell Cul
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 3-4, volume: 31, anno: 1998,
pagine: 305 - 316
SICI:
1042-8194(199810)31:3-4<305:HACOHL>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE LYMPHOBLASTIC-LEUKEMIA; EPSTEIN-BARR-VIRUS; POSITIVE PHILADELPHIA-CHROMOSOME; ACUTE PROMYELOCYTIC LEUKEMIA; AMERICAN BURKITTS-LYMPHOMA; IN-VITRO MODELS; RED BLOOD-CELLS; MYELOID-LEUKEMIA; MYELOGENOUS LEUKEMIA; HODGKINS-DISEASE;
Keywords:
cell culture; cell lines; leukemia; lymphoma; hematopoiesis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
127
Recensione:
Indirizzi per estratti:
Indirizzo: Drexler, HG DSMZ,tures,n Collect Microorgan & Cell Cultures, Dept Human & Anim Cell Cul DSMZ Mascheroder Weg 1 B Braunschweig Germany D-38124 ell Cul
Citazione:
H.G. Drexler e J. Minowada, "History and classification of human leukemia-lymphoma cell lines", LEUK LYMPH, 31(3-4), 1998, pp. 305-316

Abstract

Continuous human leukemia-lymphoma cell lines have become indispensable tools in hematological research since the establishment of the first human lymphoma cell line Raji in 1963. We summarize here historical landmarks in the establishment of unique leukemia-lymphoma-derived cell lines from the various cell lineages, their special importance in hematopoietic research is emphasized. The first cell lines were derived from African Burkitt lymphomasand were found to integrate the Epstein-Barr virus in their genome leadingto the discovery and isolation of this virus. However, it was later recognized that not every cell line derived from a patient with leukemia-lymphomarepresents a malignant cell line as residual normal B-lymphocytes can alsobe immortalized by EBV infection. During the following 20-30 years many other types of hematopoietic cell lines, commonly derived from hematopoietic neoplasms, were established. These panels of cell lines now span almost thewhole spectrum of hematopoietic cell lineages (except for dendritric cells) and the various distinct stages of differentiation along the respective cell axes. From early on, cell lines became important tools for basic and clinical hematological research, initially mainly in the field of immunology,but later expanding to other areas also. It became apparent that leukemia-lymphoma cell lines are of monoclonal origin, are arrested at a discrete maturational stage during differentiation in each lineage, and show sustainedand growth factor-independent or -dependent unlimited proliferation. Categorization of cell lines might best be based on the physiological stages of hematopoietic differentiation in the various cell lineages. For an adequateclassification, detailed characterizations of both the cell lines and the primary cells from which the cell lines originated are absolutely mandatory. In summary, the availability of large numbers of continuous leukemia-lymphoma cell lines has greatly facilitated clinical and immunobiological studies of normal and malignant hematopoiesis. Human leukemia-lymphoma cell lines will continue to provide exquisite model systems for many biomedical disciplines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:55:24