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Titolo:
Early life stress, negative paternal relationships, and chemical intolerance in middle-aged women: Support for a neural sensitization model
Autore:
Bell, IR; Baldwin, CM; Russek, LGS; Schwartz, GER; Hardin, EE;
Indirizzi:
Tucson Vet Affairs Med Ctr, Dept Psychiat, Tucson, AZ 85723 USA Tucson VetAffairs Med Ctr Tucson AZ USA 85723 hiat, Tucson, AZ 85723 USA Univ Arizona, Dept Psychiat, Tucson, AZ USA Univ Arizona Tucson AZ USAUniv Arizona, Dept Psychiat, Tucson, AZ USA Univ Arizona, Dept Psychol, Tucson, AZ USA Univ Arizona Tucson AZ USAUniv Arizona, Dept Psychol, Tucson, AZ USA Univ Arizona, Dept Neurol, Tucson, AZ USA Univ Arizona Tucson AZ USAUniv Arizona, Dept Neurol, Tucson, AZ USA Univ Arizona, Dept Family & Community Med, Tucson, AZ USA Univ Arizona Tucson AZ USA , Dept Family & Community Med, Tucson, AZ USA Univ Arizona, Dept Med, Tucson, AZ USA Univ Arizona Tucson AZ USAUniv Arizona, Dept Med, Tucson, AZ USA Univ Arizona, Resp Sci Ctr, Tucson, AZ USA Univ Arizona Tucson AZ USAUniv Arizona, Resp Sci Ctr, Tucson, AZ USA
Titolo Testata:
JOURNAL OF WOMENS HEALTH
fascicolo: 9, volume: 7, anno: 1998,
pagine: 1135 - 1147
SICI:
1059-7115(199811)7:9<1135:ELSNPR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TIME-DEPENDENT SENSITIZATION; ORGANIC-SOLVENT EXPOSURE; CHRONIC FATIGUE SYNDROME; SELF-REPORTED STRESSORS; SEXUALLY ABUSED GIRLS; BEHAVIORAL SENSITIZATION; SOMATIZATION DISORDER; ENVIRONMENTAL ILLNESS; DOPAMINE RELEASE; ODOR INTOLERANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
86
Recensione:
Indirizzi per estratti:
Indirizzo: Bell, IR Tucson Vet Affairs Med Ctr, Dept Psychiat, Mail Stop 4-116A,3601 S 6th Ave, Tucson Vet Affairs Med Ctr Mail Stop 4-116A,3601 S 6th Ave Tucson AZ USA 85723
Citazione:
I.R. Bell et al., "Early life stress, negative paternal relationships, and chemical intolerance in middle-aged women: Support for a neural sensitization model", J WOMENS HE, 7(9), 1998, pp. 1135-1147

Abstract

This study (n(total) = 35) compared early life stress ratings, parental relationships, and health status, notably orthostatic blood pressures, of middle-aged women with low-level chemical intolerance (CI group) and depression, depressives without CI (DEP group), and normals. Environmental chemical intolerance is a symptom of several controversial conditions in which womenare overrepresented, that is, sick building syndrome, multiple chemical sensitivity, chronic fatigue syndrome, and fibromyalgia. Previous investigators have postulated that people with CI have variants of somatization disorder, depression, posttraumatic stress disorder (PTSD) initiated by childhoodabuse or a toxic exposure event. One neurobehavioral model for CI, somatization disorder, recurrent depression, and PTSD is neural sensitization, that is, the progressive amplification of host responses (e.g., behavioral, neurochemical) to repeated intermittent stimuli (e.g., drugs, chemicals, endogenous mediators, stressors). Females are more vulnerable to sensitization than are males. Limbic and mesolimbic pathways mediate central nervous system sensitization. Although both CI and DEP groups had high levels of life stress and past abuse, the CI group had the most distant and weak paternal relationships and highest limbic somatic dysfunction subscale scores. Only the CI group showed sensitization of sifting blood pressures over sessions. Together with prior evidence, these data are consistent with a neural sensitization model for CI in certain women. The findings may have implications for poorer long-term medical as well as neuropsychiatric health outcomes ofa subset of women with CI. Subsequent research should test this model in specific clinical diagnostic groups with CI.

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Documento generato il 27/01/21 alle ore 02:49:19