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Titolo:
EFFICACY OF ANTICANCER ALKYLPHOSPHOCHOLINES IN TRYPANOSOMA-BRUCEI SUBSPECIES
Autore:
KONSTANTINOV SM; KAMINSKY R; BRUN R; BERGER MR; ZILLMANN U;
Indirizzi:
DEUTSCH KREBSFORSCHUNGSZENTRUM,AG TOXIKOL & CHEMOTHERAPIE,NEUENHEIMERFELD 280 D-69120 HEIDELBERG GERMANY DEUTSCH KREBSFORSCHUNGSZENTRUM,AG TOXIKOL & CHEMOTHERAPIE D-69120 HEIDELBERG GERMANY SWISS TROP INST CH-4002 BASEL SWITZERLAND DEUTSCH KREBSFORSCHUNGSZENTRUM,ZENT TIERLAB D-69120 HEIDELBERG GERMANY
Titolo Testata:
Acta Tropica
fascicolo: 3-4, volume: 64, anno: 1997,
pagine: 145 - 154
SICI:
0001-706X(1997)64:3-4<145:EOAAIT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEXADECYLPHOSPHOCHOLINE; EQUIPERDUM; EVANSI;
Keywords:
ALKYLPHOSPHOCHOLINES; CHEMOTHERAPY; GROWTH INHIBITION; HEXADECYLPHOSPHOCHOLINE; TRYPANOSOMATIDAE; TRYPANOSOMA BRUCEI SUBSPECIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Konstantinov et al., "EFFICACY OF ANTICANCER ALKYLPHOSPHOCHOLINES IN TRYPANOSOMA-BRUCEI SUBSPECIES", Acta Tropica, 64(3-4), 1997, pp. 145-154

Abstract

Tetradecylphosphocholine (TPC), hexadecylphosphocholine (HPC), hexadecylphospho(N-N-N-trimethyl)hexanolamine (HPC6), octadecylphosphocholine (OPC), and octadecyl-[2-(N-methylpiperidinio)ethyl]-phosphate (OMPEP) were investigated for antitrypanosomal activity in vitro and in vivo. OMPEP showed the best trypanocidal efficacy in vitro: it was superior to the model compound HPC and comparable to the reference compound alpha-DFMO. HPC showed moderate activity in vivo in terms of increased life expectancy (up to 35% in the acute NMRI-mouse model or 49% if combined with phenylbutazone) and increased packed cell volume, if administered daily. However, HPC and the other alkylphosphocholines failed to prolong survival time of treated mice if given intermittently. Phenylbutazone had no own trypanocidal effect but increased the efficacy ofalkylphosphocholines in vitro and in vivo: the combination of HPC andphenylbutazone acted apparently synergistic. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 16:21:49