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Titolo:
Clinical characteristics and coronary risk factors of patients with low concentrations of serum low-density lipoprotein cholesterol and total cholesterol
Autore:
Lien, WP; Lai, LP; Hwang, JJ; Lin, JL; Chen, JJ; Tsai, KS;
Indirizzi:
Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan Natl Taiwan Univ Hosp Taipei Taiwan 100 Internal Med, Taipei 100, Taiwan Natl Taiwan Univ Hosp, Dept Lab Med, Taipei 100, Taiwan Natl Taiwan Univ Hosp Taipei Taiwan 100 Dept Lab Med, Taipei 100, Taiwan
Titolo Testata:
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
fascicolo: 11, volume: 97, anno: 1998,
pagine: 745 - 749
SICI:
0929-6646(199811)97:11<745:CCACRF>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
THERAPY; DISEASE;
Keywords:
low-density lipoprotein cholesterol; total cholesterol; coronary risk factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Lien, WP Natliwanwan Univ Hosp, Dept Internal Med, 7 Chung Shan S Rd, Taipei 100, Ta Natl Taiwan Univ Hosp 7 Chung Shan S Rd Taipei Taiwan 100 00, Ta
Citazione:
W.P. Lien et al., "Clinical characteristics and coronary risk factors of patients with low concentrations of serum low-density lipoprotein cholesterol and total cholesterol", J FORMOS ME, 97(11), 1998, pp. 745-749

Abstract

Mie in investigated the clinical characteristics and coronary risk factorsof Chinese patients with suspected coronary artery disease (CAD) having low serum concentrations of both low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC). Of 1,450 patients with suspected CAD (age range, 30-92 years; 948 men and 502 women), 760 had established CAD. The patients were divided into three groups according to lipid profile patterns. Group1 patients (n = 138) had low LDL-C concentrations (< 100 mg/dL) and low TCconcentrations (< 160 mg/dL). They were characterized by lower triglyceride concentrations, lower frequencies of high TC/high-density lipoprotein cholesterol (HDLC) ratios (> 5) and LDLC/HDL-C ratios (> 5), and lower frequencies of a family history of CAD and obesity. Group 3 patients (n = 610) hadLDL-C concentrations of 130 mg/dL or above and TC concentrations of 200 mg/dL or above, much higher than in group 1. The prevalence of CAD was 41.3% (57/138) in group 1, 46.7% (328/702) in group 2, and 61.5% (375/610) in group 3. Groups with higher TC and LDL-C concentrations had a higher CAD prevalence. Coronary risk factors of group 1 patients appeared to be low HDL-C concentration, high TC/HDL-C ratio, advanced age, cigarette smoking, hypertension, and diabetes mellitus. Among these risk factors, HDL-C and hypertension were independent predictors of CAD. Unlike in the other two groups, hypertension was the only independent nonlipid risk factor. We conclude that in therapy or prevention of CAD, the goals should be to reduce LDL-C concentration to below 100 mg/dL and the TC concentration to below 160 mg/dL. However, other risk factors should also be considered.

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Documento generato il 03/12/20 alle ore 05:51:47