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Titolo:
POSITRON EMISSION TOMOGRAPHY AND FLUORODEOXYGLUCOSE STUDIES OF METABOLIC HYPERFRONTALITY AND PSYCHOPATHOLOGY IN THE PSILOCYBIN MODEL OF PSYCHOSIS
Autore:
VOLLENWEIDER FX; LEENDERS KL; SCHARFETTER C; MAGUIRE P; STADELMANN O; ANGST J;
Indirizzi:
UNIV ZURICH,HOSP PSYCHIAT,RES DEPT,POB 68 CH-8029 ZURICH SWITZERLAND PAUL SCHERRER INST,PET DEPT VILLIGEN SWITZERLAND
Titolo Testata:
Neuropsychopharmacology
fascicolo: 5, volume: 16, anno: 1997,
pagine: 357 - 372
SICI:
0893-133X(1997)16:5<357:PETAFS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYSERGIC-ACID DIETHYLAMIDE; CEREBRAL BLOOD-FLOW; HALLUCINOGENIC DRUG-INTERACTIONS; BRAIN GLUCOSE-METABOLISM; LIVING HUMAN-BRAIN; SCHIZOPHRENIC-PATIENTS; RAT-BRAIN; SEROTONIN RECEPTORS; 5-HT2 RECEPTORS; FRONTAL-CORTEX;
Keywords:
PSILOCYBIN; MODEL PSYCHOSIS; 5-HT2 RECEPTOR; PSYCHOPATHOLOGY; HUMAN; PET; [F-18] FLUORODEOXYGLUCOSE (FDG); SCHIZOPHRENIA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
114
Recensione:
Indirizzi per estratti:
Citazione:
F.X. Vollenweider et al., "POSITRON EMISSION TOMOGRAPHY AND FLUORODEOXYGLUCOSE STUDIES OF METABOLIC HYPERFRONTALITY AND PSYCHOPATHOLOGY IN THE PSILOCYBIN MODEL OF PSYCHOSIS", Neuropsychopharmacology, 16(5), 1997, pp. 357-372

Abstract

The effects of the indolehallucinogen psilocybin, a mixed 5-HT2 and 5-HT1 agonist, on regional cerebral glucose metabolism were investigated in 10 healthy volunteers with PET and [F-18]-fluorodeoxyglucose (FDG) prior to and following a 15- or 20-mg dose of psilocybin. Psychotomimetic doses of psilocybin were found to produce a global increase in cerebral metabolic rate of glucose (CMRglu) with significant and most marked increases in the frontomedial and frontolateral cortex (24.3%), anterior cingulate (24.9%), and temporomedial cortex (25.3%). Somewhatsmaller increases of CMRglu were found in the basal ganglia (18.5%), and the smallest increases were found in the sensorimotor (14.7%) and occipital cortex (14.4%). The increases of CMRglu in. the prefrontal cortex, anterior cingulate, temporomedial cortex, and putamen correlated positively with psychotic symptom formation, in particular with hallucinatory ego disintegration. The present data suggest that excessive 5-HT2, receptor activation results in it hyperfrontal metabolic pattern that parallels comparable metabolic findings associated with acute psychotic episodes in schizophrenics and contrasts with the hypofrontality in chronic schizophrenic patients. (C) 1997 American College of Neuropsychopharmacology.

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Documento generato il 24/01/20 alle ore 12:47:28