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Titolo:
FUNCTIONAL MAGNETIC-RESONANCE-IMAGING IN SCHIZOPHRENIA - INITIAL METHODOLOGY AND EVALUATION OF THE MOTOR CORTEX
Autore:
BUCKLEY PF; FRIEDMAN L; WU D; LAI S; MELTZER HY; HAACKE EM; MILLER D; LEWIN JS;
Indirizzi:
CASE WESTERN RESERVE UNIV HOSP,DEPT PSYCHIAT,11100 EUCLID AVE CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT RADIOL CLEVELAND OH 44106 UNIV WASHINGTON,MALLINCKRODT INST RADIOL ST LOUIS MO 00000
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 1, volume: 74, anno: 1997,
pagine: 13 - 23
SICI:
0925-4927(1997)74:1<13:FMIS-I>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORY STIMULATION; TARDIVE-DYSKINESIA; BLOOD-FLOW; BRAIN; MRI; ABNORMALITIES; RESOLUTION; CONTRAST; SIGNAL; SPECTROSCOPY;
Keywords:
SCHIZOPHRENIA; FUNCTIONAL MRI; MOTOR CORTEX; IMAGING; NEURAL ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
P.F. Buckley et al., "FUNCTIONAL MAGNETIC-RESONANCE-IMAGING IN SCHIZOPHRENIA - INITIAL METHODOLOGY AND EVALUATION OF THE MOTOR CORTEX", PSYCHIATRY RESEARCH-NEUROIMAGING, 74(1), 1997, pp. 13-23

Abstract

The purpose of the present study was to evaluate the differential activation of the motor cortex during finger tapping in patients with schizophrenia using the newly available imaging method of functional magnetic resonance imaging (fMRI). Nine patients with DSMIII-R schizophrenia and 9 well-matched healthy volunteer subjects underwent fMRI examination on a conventional MR unit; activation of the primary motor cortex was evaluated during performance of a finger motion task. Localized activation of the motor cortex was observed in 17 of 18 subjects during fMRI. Patients and controls were, however, indistinguishable with respect to signal intensity or area thereof within the motor cortex. fMRI did not reveal motor cortical dysfunction in schizophrenia. Despite its infancy, fMRI holds considerable promise to advance understanding of the neurodynamics of psychiatric disorders, particularly schizophrenia. (C) 1997 Elsevier Science Ireland Ltd.

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Documento generato il 05/04/20 alle ore 09:50:40