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Titolo:
Later onset of apoptosis in the bulbourethral glands after castration compared to that in the seminal vesicles
Autore:
Tsuji, M; Terada, N; Sugihara, A; Tsujimura, T; Donjacour, AA; Cunha, GR;
Indirizzi:
Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Itami City Hosp, Dept Pathol, Itami, Hyogo, Japan Itami City Hosp Itami Hyogo Japan Hosp, Dept Pathol, Itami, Hyogo, Japan Hyogo Coll Med, Dept Pathol, Nishinomiya, Hyogo, Japan Hyogo Coll Med Nishinomiya Hyogo Japan Pathol, Nishinomiya, Hyogo, Japan
Titolo Testata:
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
fascicolo: 2, volume: 67, anno: 1998,
pagine: 113 - 118
SICI:
0960-0760(199810)67:2<113:LOOAIT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; MESENCHYMAL EPITHELIAL INTERACTIONS; RAT VENTRAL PROSTATE; TISSUE RECOMBINANTS; ANDROGEN; GROWTH; MORPHOGENESIS; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Terada, N Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USAUniv Calif San Francisco San Francisco CA USA 94143 A 94143 USA
Citazione:
M. Tsuji et al., "Later onset of apoptosis in the bulbourethral glands after castration compared to that in the seminal vesicles", J STEROID B, 67(2), 1998, pp. 113-118

Abstract

Androgens affect many different target organs within the male reproductivetract to stimulate their development and secretory cytodifferentiation, and to maintain structure and function in adulthood. Castration causes regression of these organs via apoptosis. However, not all organs of the reproductive tract are equally sensitive to androgen withdrawal. The effects of castration on the mouse seminal vesicles (SVs) and bulbourethral glands (BUGs)were compared in terms of protein and DNA contents, epithelial apoptosis, and proliferative response of epithelial cells to androgen. Castration induced similar, marked decreases in protein contents in the SV and BUG by 2 days after castration which reached a minimum at 16 days post castration. Both organs underwent a decrease in DNA content, but the kinetics of this decline differed. In the SV, DNA content was significantly decreased by 4 days whereas in the BUG this did not occur until 16 days post castration. By day16 both organs had regressed to roughly the same degree. The apoptotic index in the epithelium reflected this difference in tinting as well. Apoptotic index of the SV epithelium was highest on day 3 after castration and declined thereafter. On the other hand, the apoptotic index in the BUG didn't begin to increase until 7 days after castration and became maximal on day 12. Daily injections of testosterone propionate (TP) from day 8, 16, or 30 after castration all increased epithelial labelling index in the SVs to a similar degree. However, the TP-induced increase in the epithelial labelling index in the BUG beginning on day 8 after castration was considerably less than that in BUGs receiving TP treatment from day 16 or 30 after castration. Thus, the proliferative response of the epithelium depended upon prior apoptosis in the gland, with the timing being delayed in the BUG as compared with the SV. The present results indicate that castration induces epithelialapoptosis and reduction in glandular DNA content considerably later in theBUG than in the SV though reduction in protein content in the BUG fell. simultaneously with that in the SV. (C) 1998 Elsevier Science Ltd. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 02:16:22