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Titolo:
USING A REGRESSION APPROACH TO STUDY THE INFLUENCE OF MALE FETUSES ONTHE GENITAL MORPHOLOGY OF NEONATAL FEMALE RATS
Autore:
HOUTSMULLER EJ; THORNTON JA; ROWLAND DL;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,BEHAV PHARMACOL RES UNIT BALTIMORE MD 21224 ERASMUS UNIV ROTTERDAM,FAC MED & HLTH SCI,DEPT ENDOCRINOL & REPROD NL-3000 DR ROTTERDAM NETHERLANDS EASTERN MICHIGAN UNIV,DEPT ECON YPSILANTI MI 48197 VALPARAISO UNIV VALPARAISO IN 46383
Titolo Testata:
Multivariate behavioral research
fascicolo: 1, volume: 32, anno: 1997,
pagine: 77 - 94
SICI:
0027-3171(1997)32:1<77:UARATS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEXUAL-BEHAVIOR; INTRAUTERINE POSITION; MONGOLIAN GERBILS; UTERINE POSITION; FETAL RATS; TESTOSTERONE; UTERUS; MASCULINIZATION; PHENOTYPE; INUTERO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
CompuMath Citation Index
CompuMath Citation Index
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
E.J. Houtsmuller et al., "USING A REGRESSION APPROACH TO STUDY THE INFLUENCE OF MALE FETUSES ONTHE GENITAL MORPHOLOGY OF NEONATAL FEMALE RATS", Multivariate behavioral research, 32(1), 1997, pp. 77-94

Abstract

Among newborn female rats considerable variability is found in genital morphology (e.g., anogenital distance, AGD). Presumably, such differences are related to prenatal androgen exposure, with greater exposureresulting in larger AGD's and thus in a trend toward masculinization. The source of prenatal androgen in female fetuses is unclear, but a role for male uterine mates has been implicated. The present study investigated the effect of a number of prenatal factors related to number and position of males in utero on female AGD in two strains of rats. Because such prenatal factors often show systematic covariance, a methodology was used that enabled statistical control over variables that could not be experimentally controlled. Results confirmed the importance of caudal males to female AGD, and identified two additional intra-uterine variables salient to female genital masculinization, namely thedistance of the female fetus from the nearest caudal male, and the overall number of males sharing the same uterine horn. An increase in number of adjacent males was, contrary to previous reports, associated with a decrease in AGD, but this effect was limited to one strain. There was considerable variation in AGD across the two strains, and, more importantly, across litters, suggesting the importance of factors impacting the litter as a whole rather than specific individuals within the litter.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 10:11:57