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Titolo:
The arterial baroreceptor reflex of the rat exhibits positive feedback properties at the frequency of Mayer waves
Autore:
Bertram, D; Barres, C; Cuisinaud, G; Julien, C;
Indirizzi:
FacLyonrm Lyon, CNRS, Dept Physiol & Pharmacol Clin, Sci ESA 5014, F-69373Fac Pharm Lyon Lyon France 08 ol & Pharmacol Clin, Sci ESA 5014, F-69373
Titolo Testata:
JOURNAL OF PHYSIOLOGY-LONDON
fascicolo: 1, volume: 513, anno: 1998,
pagine: 251 - 261
SICI:
0022-3751(19981115)513:1<251:TABROT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPECTRAL-ANALYSIS; HEART-RATE; BLOOD-PRESSURE; CARDIOVASCULAR VARIABILITY; CONSCIOUS RATS; OSCILLATIONS; NERVE; CIRCULATION; INVOLVEMENT; MODULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Julien, C Facckefeller,n, CNRS, Dept Physiol & Pharmacol Clin, Sci ESA 5014, 8 Ave Ro Fac Pharm Lyon 8 Ave Rockefeller Lyon France 08 5014, 8 Ave Ro
Citazione:
D. Bertram et al., "The arterial baroreceptor reflex of the rat exhibits positive feedback properties at the frequency of Mayer waves", J PHYSL LON, 513(1), 1998, pp. 251-261

Abstract

1. Modelling studies have led to the proposal that Mayer waves (similar to0.4 Hz in rats) could result from a resonance phenomenon in a feedback control loop. In this study, we investigated the presence of a resonance frequency in the arterial baroreceptor reflex loop, i.e. a particular frequency at which arterial pressure feeds back positively to the baroreceptors.2. Frequency responses of mean arterial pressure (MAP) to aortic depressornerve (ADN) stimulation were studied in fifteen urethane anaesthetized, ventilated rats with cardiac autonomic blockade. The ADN was stimulated usingrectangular trains of impulses (2 ms, 100 Hz) delivered at frequencies ranging from 0.1 to I Hz. Phase angles between impulses and MAP were calculated using cross-spectral analysis based on a fast Fourier transform algorithm.3. Rhythmic ADN stimulation induced regular MAP oscillations at the expected frequencies that were attenuated by ol-adrenoceptor blockade and abolished after ganglionic blockade. The relationship between impulse and MAP oscillations was characterized by a strong coherence and a positive phase shiftat low frequencies, indicating that impulses led MAP with respect to the out-of-phase pattern. Deviation of the phase from the out-of-phase behaviourwas mainly due to the presence of a fixed time delay (similar to 0.8 s) between ADN stimuli and MAP changes. Phase angles fell to zero at 0.42 +/- 0.02 Hz.4. In rats, the arterial baroreceptor reflex exhibits a resonance frequency close to the frequency of spontaneously occurring Mayer waves. The reflextherefore seems the most likely origin for the Mayer waves.

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Documento generato il 03/07/20 alle ore 01:48:35