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Titolo:
Layer-specific NO dependence of long-term potentiation and biased NO release in layer V in the rat auditory cortex
Autore:
Wakatsuki, H; Gomi, H; Kudoh, M; Kimura, S; Takahashi, K; Takeda, M; Shibuki, K;
Indirizzi:
Niigata Univ, Inst Brain Res, Dept Neurophysiol, Niigata 9518585, Japan Niigata Univ Niigata Japan 9518585 Neurophysiol, Niigata 9518585, Japan Niigata Univ, Sch Med, Dept Urol, Niigata 9518585, Japan Niigata Univ Niigata Japan 9518585 ed, Dept Urol, Niigata 9518585, Japan
Titolo Testata:
JOURNAL OF PHYSIOLOGY-LONDON
fascicolo: 1, volume: 513, anno: 1998,
pagine: 71 - 81
SICI:
0022-3751(19981115)513:1<71:LNDOLP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; KITTEN VISUAL-CORTEX; NADPH-DIAPHORASE; HIPPOCAMPAL SLICES; NEURONS; DEPRESSION; INHIBITORS; INDUCTION; RECEPTORS; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Shibuki, K Niigata8585,, Inst Brain Res, Dept Neurophysiol, 1 Asahi Machi,Niigata 951 Niigata Univ 1 Asahi Machi Niigata Japan 9518585 , Niigata 951
Citazione:
H. Wakatsuki et al., "Layer-specific NO dependence of long-term potentiation and biased NO release in layer V in the rat auditory cortex", J PHYSL LON, 513(1), 1998, pp. 71-81

Abstract

1. We investigated the role of nitric oxide (NO) in the induction of long-term potentiation (LTP) in slices prepared from the rat auditory cortex.2. Tetanic stimulation of layer IV elicited LTP of field potentials in layer II-III (LTPII-III) and in layer V (LTPV). The magnitude of LTPII-III measured at 30 min after tetanic stimulation was 171 +/- 9 % (n = 15, mean +/-S.E.M. ) Of the control measured before tetanic stimulation, while that of LTP, was 138 +/- 3 % (n = 17).3. NO synthase (NOS) inhibitors had no apparent effect on LTPII-III, but LTP, was significantly suppressed (P < 0.001). This suppression of LTP, was significantly antagonized by a NO donor (P < 0.001) or a cGMP analogue (P <0.001).4. Small non-pyramidal neurones in the auditory cortex were stained viith an anti-neuronal NOX antibody. More neurones were stained with the antibodyin the deeper cortical layers.5. We measured neocortical NO release with electrochemical NO probes. Layer IV stimulation elicited significantly more NO release in layer V than in layer II-III (P < 0.001). The amplitude of the increase in NO concentrationelicited by stimulation at 20 Hz for 5 s was 380 +/- 14 pM (n = 55) in layer V and 55 +/- 8 pM (n = 5) in layer II-III.6. NO release in layer V was partially but significantly suppressed by non-NMDA (P < 0.002) or NMDA (P < 0.002) receptor antagonists. Simultaneous application of the antagonists of the two types blocked NO release almost completely.7. These results clearly indicate the NO dependence of the induction of LTPV, and the greater NO release in the deeper layer of the rat auditory cortex.

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Documento generato il 06/04/20 alle ore 08:21:33