Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PET quantification of specific binding of carbon-11-nicotine in human brain
Autore:
Muzic, RF; Berridge, MS; Friedland, RP; Zhu, N; Nelson, AD;
Indirizzi:
Case Western Reserve Univ, Dept Radiol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Dept Chem & Neurol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 12, volume: 39, anno: 1998,
pagine: 2048 - 2054
SICI:
0161-5505(199812)39:12<2048:PQOSBO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; NICOTINIC RECEPTORS; ALZHEIMERS-DISEASE; KINETIC-ANALYSIS; IN-VIVO; SITES; SMOKING; PERFORMANCE; CORTEX;
Keywords:
PET; nicotine; nicotinic binding sites; specific binding;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Muzic, RF Univ Hosp Cleveland, Div Nucl Med, Cleveland, OH 44106 USA Univ Hosp Cleveland Cleveland OH USA 44106 veland, OH 44106 USA
Citazione:
R.F. Muzic et al., "PET quantification of specific binding of carbon-11-nicotine in human brain", J NUCL MED, 39(12), 1998, pp. 2048-2054

Abstract

Previous work on the PET measured uptake of (S)-[C-11]nicotine presents conflicting findings as to whether it reflects specific binding. Methods: We studied the uptake of (R)-[C-11]nicotine and (S)-[C-11]nicotine in normal volunteers at baseline conditions and after a challenge with unlabeled (S)-nicotine to decrease the concentration of free binding sites or with CO2 to increase perfusion. We analyzed the data using two- and three-compartment models. Results: We found tissue pharmacokinetics of (R)- and (S)-[C-11]nicotine are adequately described by the two-compartment model. (S)-nicotine challenge induced small but statistically significant reductions in distribution volume (DV) of both (R)- and (S)-[C-11]nicotine. The changes in DV could not be attributed to perfusion changes because DV was not affected by CO2challenge. Although the reduction in DV indicates sensitivity of [C-11]nicotine to status of nicotinic binding sites, the small magnitude of the reduction suggests that most nicotine uptake is nonspecific. Conclusion: Although differences in DV attributable to specific binding were detected, (R)- and (S)-[C-11]nicotine are relatively poor tracers for studying nicotinic binding sites using PET.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 15:30:27