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Titolo:
Validation of left ventricular volume measurements by gated SPECT Tc-99m-labeled sestamibi imaging
Autore:
Iskandrian, AE; Germano, G; VanDecker, W; Ogilby, JD; Wolf, N; Mintz, R; Berman, DS;
Indirizzi:
Alleghenydiol, Hlth Sci, MCP Hahnemann Sch Med, Cardiovasc Res Ctr, Div Car Allegheny Univ Hlth Sci Philadelphia PA USA 19143 iovasc Res Ctr, Div Car Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA Cedars Sinai Med Ctr Los Angeles CA USA 90048 , Los Angeles, CA 90048 USA
Titolo Testata:
JOURNAL OF NUCLEAR CARDIOLOGY
fascicolo: 6, volume: 5, anno: 1998,
pagine: 574 - 578
SICI:
1071-3581(199811/12)5:6<574:VOLVVM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; MYOCARDIAL PERFUSION SPECT; EJECTION FRACTION; TL-201; TECHNETIUM-99M-SESTAMIBI; QUANTIFICATION; TECHNETIUM-99M-TETROFOSMIN; ACCURACY; MOTION; IMAGES;
Keywords:
single photon emission computed tomography; (99m)technetium-sestamibi; gated perfusion imaging; left ventricular volume;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Iskandrian, AE Alleghenydiol, Hlth Sci, MCP Hahnemann Sch Med, Cardiovasc Res Ctr, Div Car Allegheny Univ Hlth Sci 230 N Broad St,Mail Stop 471 Philadelphia PA USA 19143
Citazione:
A.E. Iskandrian et al., "Validation of left ventricular volume measurements by gated SPECT Tc-99m-labeled sestamibi imaging", J NUCL CARD, 5(6), 1998, pp. 574-578

Abstract

Background. Previous studies have shown that gated single photon emission computed tomography (SPECT) technetium 99-labeled sestamibi imaging provides accurate and reproducible measurement of left ventricular (LV) ejection fraction (EF), wall motion, and thickening. This study examined the reliability of gated SPECT sestamibi imaging in measuring LV end-diastolic volume (EDV), end-systolic volume (ESV), and stroke volume (SV),Methods and Results, Gated SPECT measurements were compared with an independent nongeometric method based on thermodilution SV and first-pass radionuclide angiographic EF (using a multicrystal gamma camera), Twenty-four patients aged 58 +/- 11 years underwent cardiac catheterization and coronary angiography for evaluation of chest pain syndromes. None had primary valvulardisease, intracardiac shunts, or atrial fibrillation, Results. The correlation between the two methods mere as follows: EDV: r = 0.89, P < .001; ESV:r = .938, P < .001; SV: r = 0.577, P < .001. Bland-Altman plots showed mean differences (+/- standard deviation [SD]) for EDV of -14.3 +/- 33.3 mt, for ESV of -0.4 +/- 23.7 mt, and for SV of -13.9 +/- 15.2 mt. The reproducibility of measuring EDV and ESV by gated SPECT was very high (r = 0.99 each). Conclusion, Gated Tc-99m-labeled sestamibi SPECT provides reproducible LV volume measurements. With validation of volume measurement, gated SPECT provides comprehensive assessment of regional and global LV function. This information is important in many patient groups such as those with ischemic cardiomyopathy, concomitant coronary and valve disease, and those who have had myocardial infarction, It will also be useful to assess the incremental value of LV volumes in risk assessment.

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Documento generato il 29/03/20 alle ore 18:10:36