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Titolo:
Clonal expansion within CD4(+) and CD8(+) T cell subsets in human T lymphotropic virus type I-Infected individuals
Autore:
Eiraku, N; Hingorani, R; Ijichi, S; Machigashira, K; Gregersen, PK; Monteiro, J; Usuku, K; Yashiki, S; Sonoda, S; Osame, M; Hall, WW;
Indirizzi:
Rockefeller Univ, Med Virol Lab, New York, NY 10021 USA Rockefeller Univ New York NY USA 10021 Virol Lab, New York, NY 10021 USA N Shore Univ Hosp, Dept Med, Manhasset, NY 11030 USA N Shore Univ Hosp Manhasset NY USA 11030 ept Med, Manhasset, NY 11030 USA Kagoshima Univ, Dept Internal Med, Kagoshima 890, Japan Kagoshima Univ Kagoshima Japan 890 pt Internal Med, Kagoshima 890, Japan Kagoshima Univ, Dept Virol, Fac Med, Kagoshima 890, Japan Kagoshima Univ Kagoshima Japan 890 Virol, Fac Med, Kagoshima 890, Japan
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 12, volume: 161, anno: 1998,
pagine: 6674 - 6680
SICI:
0022-1767(199812)161:12<6674:CEWCAC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TROPICAL SPASTIC PARAPARESIS; CYTOTOXIC LYMPHOCYTES-T; GROUP-SPECIFIC PRIMERS; HTLV-I; NEUROLOGICAL DISEASE; MYELOPATHY HAM; PROVIRAL DNA; HAM/TSP; TAX; OLIGOCLONALITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Hall, WW Natl Univ Ireland Univ Coll Dublin, Dept Med Microbiol, Dublin 4,Ireland Natl Univ Ireland Univ Coll Dublin Dublin Ireland 4 4, Ireland
Citazione:
N. Eiraku et al., "Clonal expansion within CD4(+) and CD8(+) T cell subsets in human T lymphotropic virus type I-Infected individuals", J IMMUNOL, 161(12), 1998, pp. 6674-6680

Abstract

To investigate the diversity of the T cell repertoire involved in human T lymphotropic virus type I (HTLV-I) infections, peripheral blood T cell subsets mere analyzed by using a PCR-based assay that permits determination of complementarity-determining region 3 (CDR3) length variation in TCR VP transcripts. In two of four asymptomatic HTLV-I carriers and in four of five patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), mono- or oligoclonal expansions were detected in the CD4(+) T cell subset. In one patient with adult T cell leukemia, a specific clone bearing Vbeta 7 was detected in the CD4(+) T cell subset. In contrast, clonal expansion was not observed in the CD4(+) T cell subsets of three individuals with asymptomatic HTLV-II infection or in our previous studies of a large number of uninfected individuals. Oligoclonal expansions in the CD8(+) T cell subset were detected in all subjects, including the patient with adult T cell leukemia, No differences in the number of expanded clones were noted between asymptomatic carriers and in patients with HAM/TSP and there was no obvious restriction in the TCR V region usage. Direct sequencing revealed no significant bias in the CDR3 motifs utilized by the predominant clones. Thisreport is the first direct demonstration of clonal expansions within fractionated T cell subsets (CD4(+) and CD8(+)) in HTLV-I infections and suggests that 1) clonal expansion of CD4(+) T lymphocytes likely occurs as a direct result of infection and 2) polyclonal CD8(+) T cell expansion occurs frequently and independently of disease association.

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Documento generato il 29/09/20 alle ore 23:45:15