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Titolo:
Vasoactivity of adenosine in the trout (Oncorhynchus mykiss) coronary system: Involvement of nitric oxide and interaction with noradrenaline
Autore:
Mustafa, T; Agnisola, C;
Indirizzi:
Odense Univ, Inst Biol, DK-5230 Odense M, Denmark Odense Univ Odense Denmark M Univ, Inst Biol, DK-5230 Odense M, Denmark Univ Naples, Dept Gen & Environm Physiol, Naples, Italy Univ Naples Naples Italy es, Dept Gen & Environm Physiol, Naples, Italy
Titolo Testata:
JOURNAL OF EXPERIMENTAL BIOLOGY
fascicolo: 22, volume: 201, anno: 1998,
pagine: 3075 - 3083
SICI:
0022-0949(199811)201:22<3075:VOAITT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNTHASE GENE-EXPRESSION; RAINBOW-TROUT; ADRENERGIC RESPONSES; BLOOD-FLOW; L-ARGININE; HEART; ENDOTHELIUM; EXERCISE; DOGS; PROSTACYCLIN;
Keywords:
trout; Oncorhynchus mykiss; intact coronary system; adenosine; nitric oxide; N-omega-nitro-L-arginine; noradrenaline;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Mustafa, T Odense Univ, Inst Biol, Campusvej 55, DK-5230 Odense M, DenmarkOdense Univ Campusvej 55 Odense Denmark M 30 Odense M, Denmark
Citazione:
T. Mustafa e C. Agnisola, "Vasoactivity of adenosine in the trout (Oncorhynchus mykiss) coronary system: Involvement of nitric oxide and interaction with noradrenaline", J EXP BIOL, 201(22), 1998, pp. 3075-3083

Abstract

A vasoconstrictory response to adenosine has been reported in coronary rings from fish, Since the reactivity of the large coronary arteries and the microcirculation may differ, the present study was undertaken to determine the role of adenosine in the intact coronary system of trout under constant pressure or how using an isolated and nonworking heart preparation, The involvement of nitric oxide (NO) and the interaction with noradrenaline were also studied, At 10(-9) to 10(-8) mol l(-1), adenosine caused a vasoconstrictory response, whereas between 10(-7) and 10(-5) mol l(-1) the response waspredominantly vasodilative. Theophylline abolished both these responses toadenosine. The vasodilation induced by adenosine (at 10(-5) mol l(-1)) wassignificantly reduced when the preparation was perfused under constant-flow than rather under constant-pressure conditions, The nitric oxide synthaseinhibitor N-omega-nitro-L-arginine (L-NA, 10(-4) mol l(-1)) partially reduced the vasodilation induced by adenosine (at 10(-5) mol l(-1)) under constant-pressure but not under constant-flow conditions, Perfusion of the intact coronary system with L-arginine or with adenosine significantly increasedthe rate of nitrite (NO2-) release, while perfusion with L-NA or theophylline reduced NO2- release, Chemical denudation of the coronary endothelium by CHAPS resulted in the loss of both the L-arginine- and adenosine-mediatedvasodilation and the L-arginine-induced increase in the rate of NO2- release, Adenosine (10(-5) mol l(-1)) offset and overrode the vasoconstriction induced by 10(-7) mol l(-1) noradrenaline, LNA inhibited only the adenosine-induced vasodilation but not the ability to offset noradrenaline vasoconstriction, excluding the involvement of NO in the interaction between adenosine and noradrenaline.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 11:30:05