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Titolo:
Prolongation of QT interval in isolated feline hearts by antipsychotic drugs
Autore:
Drici, MD; Wang, WX; Liu, XK; Woosley, RL; Flockhart, DA;
Indirizzi:
Georgetown Univ, Med Ctr, Dept Pharmacol, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 armacol, Washington, DC 20007 USA
Titolo Testata:
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 6, volume: 18, anno: 1998,
pagine: 477 - 481
SICI:
0271-0749(199812)18:6<477:POQIII>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
TORSADE-DE-POINTES; CARDIAC-ARRHYTHMIA; PSYCHOTROPIC-DRUGS; HALOPERIDOL; MECHANISMS; TERFENADINE; REPOLARIZATION; SCHIZOPHRENIA; SYSTEM; AGENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Woosley, RL Georgetown Univ, Med Ctr, Dept Pharmacol, 3900 Reservoir Rd NW, Washington, Georgetown Univ 3900 Reservoir Rd NW Washington DC USA 20007 ,
Citazione:
M.D. Drici et al., "Prolongation of QT interval in isolated feline hearts by antipsychotic drugs", J CL PSYCH, 18(6), 1998, pp. 477-481

Abstract

Some antipsychotic drugs have been found to prolong the QT interval on electrocardiographic (ECG) recordings, a phenomenon which, when severe, may facilitate the occurrence of complex ventricular arrhythmias such as torsade de pointes. However, the effects of these drugs on the cardiac repolarization process have not been evaluated extensively. This study was designed to examine the potency of five antipsychotic drugs in lengthening the QT interval of the perfused feline heart: haloperidol, risperidone, sertindole, clozapine, and olanzapine. The hearts were infused with increasing concentrations of drugs (0.1-20 mu mol/L) for 40-minute intervals at each concentration. ECG recordings were made, with signals amplified and data recorded on a strip chart recorder. Four representative beats from each set of three signal recordings were chosen for QT interval measurement. Our data indicated that all tested drugs prolonged the QT interval in a concentration-dependentmanner (p < 0.01). Haloperidol and risperidone were significantly more potent than sertindole, clozapine, and olanzapine (p < 0.001). At a concentration of 0.5 mu mol/L over a 40-minute infusion interval, haloperidol lengthened the interval by 26.2 +/- 0.7%, risperidone by 19.4 +/- 2.2%, and sertindole by 8.9 +/- 3.5% (p < 0.05 compared with baseline); clozapine and olanzapine were less potent. Although species differences may Limit extrapolation of our findings to humans, the cardiac potassium channels of felines clearly resemble those of humans. This model may serve as the basis for furtherstudies of drug-induced prolongation of the QT interval and precipitation of ventricular arrhythmias.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:02:28